MagNA Pure 96 System

Product image for MagNA Pure 96 System

Fully automated, high throughput nucleic acid purification

 

Start here. Go anywhere.

 

The MagNA Pure 96 System ensures purity, reproducibility, and laboratory efficiency for a successful molecular diagnostic workflow. Process up to 96 samples in less than one hour and increase your laboratory productivity to meet your changing needs.

Effortless purification, confidence from automation

  • Proven performance delivering reproducible and consistent yields
  • Process up to 96 samples in less than one hour
  • Support for a broad range of samples for use in a variety of downstream applications
  • Simplified workflow with ready-to-use prefilled reagent trays and streamlined kit offerings
  • Full traceability and connection to your laboratory information system
  • Minimized handling errors via detection, guidance and surveillance processes
  • Contamination prevention with built-in UV lamp and drop catcher plus CO-RE Tip technology

 

Prefilled, barcoded, and ready-to-use reagent kits

 

MagNA Pure 96 Kits are prefilled and ready-to-use reagent trays that can be easily loaded, ensuring ease of use and safety. Kits and consumables are barcoded and read by the MagNA Pure onboard scanner for inventory check, loading errors, and process documentation.

 

Download protocols

 

The MagNA Pure 96 System protocols are available for download from the table below (note: not available for download in the US).

Optimized preprogrammed purification protocols ensure routine sample handling and high quality, reproducible nucleic acid yields. Choose the appropriate purification protocol for your sample material and target nucleic acid.

MagNA Pure 96 System protocols

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Target Protocol name Input sample type and sample volumes Elution volume Run time*** (h:mm)
Whole blood Plasma (citrate) Plasma (EDTA) Serum Swabs BAL*
Sputum CSF Urine Stool Stool Cultured cells Fresh-frozen tissue FFPET*
Baterial, fungal and viral NA Pathogen Universal 200 1 200 μL 50, 100 μL 1:00
Viral NA Plasma SV 1 50, 100, 200 μL 1:00
Viral NA Plasma ext lys SV 1

Protocol optimized with external lysis reagent

350, 450 μl lysate from 100, 200 μl sample 1:00
Viral NA Universal SV 1 50, 100, 200 μL 50, 100, 200 μL 1:00
Pathogen Universal 500 2 500 μL 1:30
Pathogen Universal 1000 2 1000 μL 1:40
Viral NA Plasma LV 2 500 μL 1:10
Viral NA Plasma LV 1000 2 1000 μL 1:20
Viral NA Plasma ext lys LV 1

Protocol optimized with external lysis reagent

1000 μl lysate from 500 μl sample 1:10
Viral NA Universal LV 2 500 μL 500 μL 1:30
Viral NA Universal LV 1000 2 1000 μL 1000 μL 1:30
Genomic DNA DNA Blood SV 1 ≤ 2x106 cells/samples 50, 100 μL 1:00
DNA Blood ext lys SV 1

Protocol optimized with external lysis reagent

300, 350, or 450 μl lysate from
50, 100, 200 μl sample
0:50
DNA Cells SV 1 Up to 5x105 cultured cells in 200 μl PBS 100 μl 1:00
DNA Tissues SV 1 Up to 5mg in 200 μl 100, 200 μl 1:20
DNA FFPE SV 1 200 μl lysate from 2x5 μl sections 50, 100 μl 1:00
DNA Blood LV 2 500 μL(≤ 1x107 cells/ml) 100, 200 μL 1:20
DNA Blood LV 1000 2 1000 μL(≤ 1x107 cells/ml) 1:30
DNA Blood ext lys LV 2

Protocol optimized with external lysis reagent

1000 μl lysate from 500 μl sample (≤ 1x107 cells/ml) 100, 200 μl 0:50
DNA Cells LV 1 Up to 1x106 cultured cells in 200 μl PBS 100, 200 μl 1:20
DNA Tissue LV 2 Up to 25mg in 200 μl 200 μl 1:20
Cell-free NA cfNA ss 2000 2

Protocol optimized for single-stranded DNA

2000 μL 50, 100 μL 2:00
cfNA ss 4000 2

Protocol optimized for single-stranded DNA

4000 μL 2:20
cfNA ds 2000 2

Protocol optimized for single-stranded DNA

2000 μL 100, 200 μL 2:20
cfNA ds 4000 2

Protocol optimized for single-stranded DNA

4000 μL 2:50
Total RNA Cellular RNA LV 3 Up to 1x106 cultured cells in 200 μl PBS 50, 100, 200 μl 1:30
RNA Blood LV 400 3 900μl stabilized whole blood from 400 μl whole blood 50, 100, 200 μl 1:30
RNA Blood LV 800 3 1800μl stabilized whole blood from 800 μl whole blood 100, 200 μl 1:30
RNA PAXgene LV 3 PAXgene pellet in 400 μl PBS 100, 200 μl 1:30
RNA PAXgene Half Tube LV 3 Half PAXgene pellet in 200 μl PBS 50, 100 μl 1:30
RNA Tissue FF Standard LV 3 Up to 10mg in 350 μl 50, 100, 200 μl 1:30
RNA Tissue FF High LV 3 Up to 25mg in 700 μl 100, 200 μl 1:30
RNA Tissue FFPE LV 3 150 μl lysate from 2x5 μm sections 50, 100 μl 1:30
Liquid handling Sample Transfer
to the processing cartridge
NA
Archive Plate Transfer
for archiving purposes
5 μl to 200 μl NA
PCR Setup with Mixing NA
PCR Setup without Mixing NA

1 MagNA Pure 96 DNA and Viral NA Small Volume Kit (cat. no. 06 543 588 001)
2 MagNA Pure 96 DNA and Viral NA Large Volume Kit (cat. No. 06 374 891 001)
3 MagNA Pure 96 Cellular RNA Large Volume Kit (cat no. 05 467 535 001)

To get better results, Roche provides various External Lysis Buffers: MagNA Pure cfNA Buffer Set (Cat. no. 07 794 398 001), MagNA Pure 96 External Lysis Buffer (Cat. no. 06 374 913 001), MagNA Pure 96 Bacterial Lysis Buffer (Cat. no. 06 374 921 001), MagNA Pure 96 DNA Tissue Lysis Buffer (Cat. no. 06 640 702 001), MagNA Pure FFPET Buffer Set† (Cat. no. 08 447 144 001) and S.T.A.R. Buffer§ (Cat. no. 03 335 208 001). Please refer to the instructions for use manual for more details.

*BAL - Bronchoalveolar Lavage
**FFPET - formalin-fixed paraffin-embedded tissue
***These times are approximate and should only be used as a guidance.
For general laboratory use.
§For life science research only. Not for use in diagnostic procedures.

An intuitive user interface

MagNA Pure 96 Software includes an intuitive graphical user interface, providing all instructions to operate the system, such as sample loading to run start. The software detects loading errors and provides information to the user for the appropriate corrective action.

 

A new dimension in productivity

 

Experience high throughput automation combined with high performance while increasing your laboratory productivity to meet your changing needs. Magnify your lab’s efficiency with seamless data management and expand your capacity for diverse day to day throughput needs.

 

Further information

 

For more detailed information about the MagNA Pure 96 System, visit magnapure96.com.

 

Registration status

IVD

Package inserts

Access package inserts through your country’s Roche Diagnostics website.