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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "Anti-CD44 (SP37) Rabbit Monoclonal Primary Antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of anti-CD44 (SP37) contains approximately 3.5 μg of a rabbit monoclonal antibody.
The antibody is diluted in Tris-HCl dilution buffer with Brij-35, 1% carrier protein, and 0.1% ProClin 300, a preservative.
otal protein concentration of the reagent is approximately 10 mg/mL.
Specific antibody concentration is approximately 0.7 μg/mL. There is no known non-specific antibody reactivity observed in this product.
Anti-CD44 (SP37) is a recombinant monoclonal antibody produced from supernatant material.
Refer to the appropriate VENTANA detection kit package insert for detailed descriptions of: (1) Principles of the Procedure, (2) Materials and Reagents Needed but Not Provided, (3) Specimen Collection and Preparation for Analysis, (4) Quality Control Procedures, (5) Troubleshooting, (6) Interpretation of Results, and (7) General Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "L’anticorps Anti-CD44 (SP37) Rabbit Monoclonal Primary Antibody est dirigé contre la protéine CD44. Le CD44 est une protéine du récepteur transme\u0002mbranaire de type I exprimée dans plusieurs types de cellules, notamment les lymphocytes T et B, les monocytes,les granulocytes, les érythrocytes, les fibroblastes, les cellules épithéliales et les mastocytes. Cet anticorps présente un profil de coloration membranaire et peut être utilisé pour détecter l’isoforme CD44 standard ainsi que ses variantes dans divers tissus néoplasiques, notamment le carcinome épidermoïde et le carcinome urothélial.

L’anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine. L’évaluation doit être effectuée par un pathologiste qualifié conjointement à un examen histologique, aux informations cliniques pertinentes et aux contrôles appropriés. Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV)", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Anti-CD44 (SP37) is a rabbit monoclonal antibody produced against a conserved region of the CD44 protein. CD44 is expressed in many normal human hematopoietic, epithelial,and mesenchymal cells. Functionally, CD44 is involved in lymphocyte recirculation, adhesion, activation, lymph node homing, and to a larger extent in other tissue types, cell- cell and cell-matrix interactions.^1,2,3,4 CD44 is one of two major hyaluronan (HA) binding proteins required for activation of hyaluronan.^1,2,3,4 Together, HA and CD44 are involved in enhanced cell signaling and locomotion; both are expressed abundantly during morphogenesis as well as physiological and pathological invasive processes.^1,2 The extensive glycosylation patterns of CD44 are important for the recognition and binding of the CD44-hyaluronan complex.⁵ The CD44 molecule is known to present several different glycosylation, oligomerization, and protein sequence patterns due to differential mRNA splicing.^2,3,4 There are 10 variants of CD44 due to differential splicing.^3,4 Five of the ten are located in the extracellular domain of the protein.³ Changes in the regulation of the different variant expression patterns in a variety of tissue types has been associated with differing prognosis.^{3,4,6,7,8,9,10}

1. Aruffo A, Stamenkovic I, et al.CD44 is the principal cell surface receptor for hyaluronate. Cell 1990;61:13.
2. Hascall V, Esko J. “Hyaluronan”. Essentials of Glycobiology (2nd). Chapter 15. Cold Spring Harbor Laboratory Press; 2008.
3. Endo K., Terada T. Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival. J. of Hepatology. 2000;32:78-84.
4. Southgate J., Trejdosiewicz L. et al.Patterns of splice variant CD44 expression by normal human urothelium in situ and in vitro and by bladder-carcinoma cell lines. Int. J. Cancer. 1995;62:449-456.
5. Bartolazzi A., Nocks A., et al.Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. JCB. 1996;132(6):1199-1208.
6. Horny H-P, Menke DM, et. al.Neoplastic human tissue mast cells express the adhesion molecule CD44/HCAM. Virchows Arch 1996;429:91-4.
7. McKenney J., Desai S., et. al.Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium: An analysis of Cytokeratin 20, p53, and CD44 antigens. The American Journal of Surgical Pathology: August 2001;25(8): 1074-1078.
8. Simpson R.,Wells A., et al.Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. Am. J. Pathol. 2010;176:1215-1228.
9. Ouhtit A., Elmageed Z., et al.In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver. Am. J. Pathol. 2007;171:2033-2039.
10. Mathew J., Hines J., et al.CD44 is expressed in hepatocellular carcinomas showing vascular invasion. J. of Pathol. 1996;179:74-79.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Product Purpose", "Value": "L’anticorps Anti-CD44 (SP37) Rabbit Monoclonal Primary Antibody est dirigé contre la protéine CD44. Le CD44 est une protéine du récepteur transme\u0002mbranaire de type I exprimée dans plusieurs types de cellules, notamment les lymphocytes T et B, les monocytes,les granulocytes, les érythrocytes, les fibroblastes, les cellules épithéliales et les mastocytes. Cet anticorps présente un profil de coloration membranaire et peut être utilisé pour détecter l’isoforme CD44 standard ainsi que ses variantes dans divers tissus néoplasiques, notamment le carcinome épidermoïde et le carcinome urothélial.

L’anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine. L’évaluation doit être effectuée par un pathologiste qualifié conjointement à un examen histologique, aux informations cliniques pertinentes et aux contrôles appropriés. Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV)", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }