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"ProductSpec": [
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"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "Anti-EGFR L858R (SP125) contains sufficient reagent for 50 tests.
One 5mL dispenser of anti-EGFR L858R (SP125) contains approximately 19 µg of a rabbit monoclonal antibody.
The antibody is diluted in a phosphate buffer with carrier protein and ProClin 300, a preservative. Total protein concentration of the reagent is approximately 3 mg/mL.
Specific antibody concentration is approximately 3.8 µg/mL. There is no known non-specific antibody reactivity observed in this product.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "L'anti-EGFR L858R (SP125) Rabbit Monoclonal Primary Antibody (antiEGFR L858R (SP125)) présente un profil de coloration cellulaire membranaire et/ou cytoplasmique et peut être utilisé pour faciliter l'identification de la protéine mutante du récepteur du facteur de croissance épidermique, EGFR L858R. L'anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine. Ce produit doit être interprété par un anatomopathologiste qualifié, en association avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés.
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
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"Name": "Background Information",
"Value": "Anti-EGFR L858R (SP125) is a recombinant rabbit monoclonal antibody that is specific for the L858R substitution within the Epidermal GrowthFactor Receptor (EGFR) protein. EGFR is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the Her/ErbB (HER1) protein family.1,2 EGFR gene mutations are common in lung and other cancers, particularly in Asian populations and in patients that have never smoked.2 In-frame deletions occur in exon 19, whereas point mutations occur most frequently in codon 858 (exon 21). A leucine to arginine change at position 858 is the most common of the single amino acid substitutions, and the target of this antibody. The L858R substitution and deletions in exon 19, such as E746-A750, representmore than 90% of EGFR mutations in non-small cell lung cancer patients.3
1. Voldborg B, Damstrup L, et al. Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Ann Oncol. 1997;8:1197-1206.
2. Gandhi J, Zhang J, Xie Y, et al. Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines. PLoS One. 2009;4:1-11.
3. Kozu Y, Tsuta K, Kohno T, et al. The usefulness ofmutation-specific antibodies in detecting epidermal growth factor receptor mutations and in predicting response to tyrosine kinase inhibitor therapy in lung adenocarcinoma. Lung Can. 2011;73:45-50.",
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Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
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