Pre-eclampsia is a serious multi-system complication of pregnancy, occurring in 3 - 5 % of pregnancies, and it is one of the leading causes of maternal and perinatal morbidity and mortality worldwide.1-3
Pre-eclampsia is defined as new-onset of hypertension and proteinuria after 20 weeks of gestation. The clinical presentation of pre-eclampsia and subsequent clinical course of the disease can vary tremendously, making prediction, diagnosis and assessment of disease progression difficult.1-3
Angiogenic factors (sFlt-1 and PlGF) are proven to play an important role in the pathogenesis of pre-eclampsia and their concentrations in maternal serum are altered even before the onset of the disease making them a tool for prediction and aid in diagnosis of pre-eclampsia.1-3