Tau (tubulin-associated unit) protein is one of the two hallmarks of Alzheimer’s disease, besides β-Amyloid (1-42). The Elecsys Total-Tau CSF assay is designed to detect the six human brain Tau isoforms or fragments in human CSF.
Many studies show that total Tau CSF (tTau) levels increase around 2 – 3 fold in mild to moderate Alzheimer’s Disease patients compared to age matched controls while CSF β Amyloid (1-42) levels decrease to around half the level in controls.1,2 CSF tTau has been shown to reflect the intensity of the neuronal and axonal damage and degeneration. High CSF tTau is also associated with a faster progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease.3
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