{
"ProductData": {
"ID": "RTD001046",
"ProductType": "Others",
"BrandName": "MSH2 (G219-1129) Mouse Monoclonal Antibody",
"ProductNameAddition": "",
"RegulatoryDisclaimer1": "See country-specific product labeling for regulatory status.",
"DisclaimerGroup1": "Country Specific Labeling",
"RegulatoryDisclaimer2": null,
"DisclaimerGroup2": null,
"RegulatoryDisclaimer3": null,
"SampleType": [
"Formalin-Fixed Paraffin-Embedded Tissue (FFPET)"
],
"LicenseDisclaimers": [
],
"RelatedLinks": "
Cell Marque - Instructions for UseCell Marque - Safety Data Sheet",
"Clone": "G219-1129",
"ControlTissue": [
"Colon Carcinoma",
"Colon Mucosa"
],
"ISOtypes": "IgG
1",
"Species": [
"Mouse"
],
"StainLocalization": [
"Nucleus"
],
"ProductNameGlobal": "MSH2 G219-1129"
},
"ProductImageDetails": {
"ImagePath": "https://pim-media.roche.com/Images/MSH2_PS edited.jpg",
"ImageType": "Image main"
},
"Product2Taxonomy": {
"Product2TaxonomyReferences": [
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeID": "05-0002",
"StructureNodeStatus": "Active",
"NodeName": "IHC Primary Antibodies"
},
{
"StructureSystemIdentifier": "OWP_Techniques",
"StructureSystemName": "Techniques",
"NodeID": "073-00",
"StructureNodeStatus": "Active",
"NodeName": "Immunohistochemistry (IHC)"
},
{
"StructureSystemIdentifier": "Lab_Type",
"StructureSystemName": "Lab Types",
"NodeID": "080-00",
"StructureNodeStatus": "Active",
"NodeName": "Pathology Lab"
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "13-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Gastroenterology"
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "19-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Oncology"
},
{
"StructureSystemIdentifier": "Disease_Areas",
"StructureSystemName": "Disease Areas",
"NodeID": "11-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Colorectal cancer"
},
{
"StructureSystemIdentifier": "Product_Solutions",
"StructureSystemName": "Product Solutions",
"NodeID": "010",
"StructureNodeStatus": "Active",
"NodeName": "Histopathology"
},
{
"StructureSystemIdentifier": "Applications",
"StructureSystemName": "Applications",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Pathogens",
"StructureSystemName": "Pathogens",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "OWP_Product_Types",
"StructureSystemName": "Product Types",
"NodeID": "15-000-00",
"StructureNodeStatus": "Active",
"NodeName": "Primary Antibody"
},
{
"StructureSystemIdentifier": "OWP_Family",
"StructureSystemName": "Product Families",
"NodeID": "080",
"StructureNodeStatus": "Active",
"NodeName": "BenchMark"
}
]
},
"Product2Materials": {
"P2MaterialReferences": [
{
"MaterialNum": "05269270001",
"MaterialDescription": "Cell Marque, MSH-2",
"RegisteredProductName": "MSH2 (G219-1129) Mouse Monoclonal Antibody",
"GTIN": "00841683100577",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "760-4265",
"PackSizePIM360": "50 tests",
"PackSizeDescPIM360": "Not Available",
"MaterialAnnotation": "",
"ReadyForUse": "undefined",
"OrderInformation": ""
}
]
},
"Product2Products": {
"Product2ProductReference": [
{
"ProductID": "INS_2099",
"BrandName": "BenchMark ULTRA",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "2300",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA",
"StructureGroupName": "BenchMark ULTRA",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_2580",
"BrandName": "BenchMark GX",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "6151",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark GX",
"StructureGroupName": "BenchMark GX",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "999-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "INS_6476",
"BrandName": "BenchMark ULTRA PLUS",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "9570",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA PLUS",
"StructureGroupName": "BenchMark ULTRA PLUS",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
}
]
},
"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "MSH2 (G219-1129) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the MSH2 protein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "MSH2 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as hereditary nonpolyposis colon cancer (HNPCC). The anti-MSH2 antibody is useful in screening patients and families for this condition. It has been shown that colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
1-8 Anti-MSH2 is utilized in an IHC panel that includes anti-MLH1, anti-MSH6, and anti-PMS2.
1. Wright, CL et al. Histopathology and mismatch repair status of 458 consecutive colorectal carcinomas. Am J Surg Pathol. 2003; 27:1393-1406.
2. Brueckl, WM et al. Relationship between microsatellite instability, response and survival in palliative patients with colorectal cancer undergoing first-line chemotherapy. Anticancer Research 2003; 23:1773-1778.
3. Rigau, V et al. Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining. Arch Pathol Lab Med 2003 June; 127(6):694-700.
4. Renkonen, E et al. Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer. J Clin Oncol 2003; 21:3629-3637.
5. Hoedema, R et al. Genetic testing for hereditary nonpolyposis colorectal cancer. The American Surgeon 2003 May; 69(5):387-92.
6. Christensen, M et al. Antibody-based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing. Cancer 2002; 95:2422- 30.
7. Wahlberg, SS et al. Evaluation of microsatellite instability and immunohistochemistry for the prediction of germ-line MSH2 and MLH1 mutations in hereditary nonpolyposis colon cancer families. Cancer Research June 15 2002; 62:3485-3492.
8. Lanza, G et al. Immunohistochemical pattern of MLH1/MSH2 expression is related to clinical and pathological features in colorectal adenocarcinomas with microsatellite instability. Modern Pathology 2002; 15:741-749.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "MSH2 (G219-1129) Mouse Monoclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "MSH2 (G219-1129) Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the MSH2 protein in formalin-fixed, paraffin-embedded tissue stained on VENTANA BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for
in vitro diagnostic (IVD) use.",
"Language": "en",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
