Determination of subtle changes in GFR is crucial in the early detection of CKD
Serum creatinine levels only begin to rise in CKD stage 3 when approximately 50 % of renal function is already lost (“creatinine-blind area”). Subtle changes in the GFR in
CKD stages 1 and 2 – not detectable by creatinine-based measurements – can be determined by cystatin C due to its higher sensitivity and specificity.
Figure 1: Stages of chronic kidney disease according to NKF KDOQI4