Coagulation systems and tests

Making innovation routine

The coagulation system comprises the platelets and the plasma coagulation factors. Its main functions are the physiological “sealing” of vascular defects and, in the case of injuries, formation of the initial platelet plug. Additionally, the coagulation system reinforces the platelet plug with fibrin and, finally, clot retraction. Inhibitors bind excess activated clotting factors and thus prevent excessive growth of the thrombus. After injury of a blood vessel, bleeding is temporarily stopped by formation of the primary thrombus (platelet plug) within a few minutes. The platelet plug is an irreversible aggregate of platelets which have undergone profound morphological and functional changes. Coagulation testing assesses various aspects of this system and allows healthcare professionals to make appropriate treatment interventions.  Laboratory coagulation testing accounts for around one fifth of the total sample workload of the core laboratory.

With a number of industry firsts and innovative applications for early disease detection and monitoring, Roche is rapidly moving towards a new comprehensive offering for the central coagulation laboratory.  From easy low volume self-monitoring and professional monitoring at the physician's office to high efficiency demands of commercial laboratories, Roche is prepared to deliver platforms that provide outstanding productivity while reducing complexity by addressing current and future testing requirements across a broad range of customer segments.

Consistent with current Roche Professional Diagnostics instrument solutions and driven by our commitment to deliver customer driven, quality oriented and cost effective solutions, Roche will enter into a new era of testing solutions for coagulation customers.

From self-testing to laboratory automation

Whether you are working in a commercial lab, hospital lab or a hospital network, cobas solutions provide you with a broad range of innovative diagnostic tests and analyzers that play an essential role in integrated healthcare solutions.

What's more, our coagulation diagnostics solutions cover all market segments,from genetic testing and clinical laboratory systems to in-hospital, point-of-care and patient self-management testing.

Simplicity. Quality. Safety. Flexibility

Our flexible products are designed to simplify your work as healthcare professionals. The streamlining of lab processes means savings in resources and faster results, while the accuracy of the results is always uniformly high.

Systems and Tests

cobas t 411 coagulation analyzer

The new cobas t 411 analyzer is a stand-alone lab coagulation system that is suitable for low-volume routine testing (up to 120 samples per day).

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Multiplate® analyzer

Used to stratify bleeding risk and personalize anti-platelet therapy – even with small volumes of whole blood.
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Platelet stimulation via the thrombin receptor (using TRAP-6), sensitive to IIbIIIa receptor antagonists.



Used for monitoring of Aspirin® and other cycloxygenase inhibitors.


ASA reagent

Inhibitor of cyclooxygenase. Addition of ASA reagent to the blood sample leads to reduced aggregation responses in ASPItest and COLtest.


GpIIB / IIIa antagonist reagent

Inhibitor of the platelet GpIIb/IIIa receptor. Addition to a blood sample leads to strongly reduced aggregation in the TRAPtest.








vWF and GpIb dependent aggregation (using ristocetin)




Used for monitoring of clopidogrel, prasugrel and other ADP receptor antagonists.


Prostaglandin E1 reagent

For the assessment of ADPtest HS (high sensitivity) and of positive (i.e. abnormal) controls of the ADPtest.



Collagen induced aggregation.

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