Platelet function testing with best-in-class predictivity
Blood platelets play a pivotal role in physiological hemostasis, but also in the development of arterial thrombosis (myocardial infarction and stroke).
Platelet function testing is utilized in the analysis of inherited and acquired platelet function disorders that may cause a transient or permanent bleeding tendency. The Multiplate analyzer can detect platelet dysfunction and thus aid in the therapeutic management of such patients.
It can also be used for monitoring of antiplatelet drugs where both compliance and drug effectiveness are key issues. It was shown with Multiplate results1 that up to 20% of patients do not respond adequately to clopidogrel treatment. These patients have a 5 – 10 fold increased risk of stent thrombosis, stroke and myocardial infarction1- 4 following percutaneous coronary interventions. Multiplate delivers best-inclass predictivity 5 and evidence is available demonstrating that Multiplate guided antiplatelet therapy has the potential to improve patient outcome.6-8
The Multiplate analyzer also plays a role in the analysis of platelet function in anesthesia and intensive care, where platelet dysfunction can lead to severe bleeding complications. The detection or exclusion of platelet dysfunction before invasive procedures or in bleeding patients can aid the risk stratification and management in these situations.9-10
1 Sibbing, D. et al. (2009). J Am Coll Cardiol. Mar 10;53(10):849-56.
2 Sibbing, D. et al. (2010). Thromb Haemost. Jan;103(1):151-9.
3 Schulz, S. et al. (2010). Am Heart J. Aug; 160(2):355-61.
4 Siller-Matula, J.M. et al. (2010). J Thromb Haemost. Feb; 8(2):351-9.
5 Bonello, L. et al. (2010). J Am Coll Cardiol. Sep 14;56(12):919-33.
6 Siller-Matula, J.M. et al. (2013). Int J Cardiol. Sep 1; 167(5):2018-2023.
7 Sibbing, D. et al. (2012). J Am Coll Cardiol. 59; E265.
8 Aradi et al. (2013). J Am Coll Cardiol. 61(10): E1922.
9 Ranucci, M. et al. (2011). Ann Thorac Surg. Jan; 91(1):123-9.
10 Weber, C.F. et al. (2012). Anesthesiology, Sep; 117(3):531-47.
Cost-effective therapies :
Best predictivity :
Fast and easy assessment :
Consistent results :
Medical momentum :
10 Weber, C.F. et al. (2012). Anesthesiology, Sep; 117(3):531-47.
11 Straub, N. et al. (2013). Thromb Haemost. Oct 24; 111(2).