cobas p 480 Instrument

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Automating your primary vial pre-processing steps

Flexible pre-analytic workflows

The cobas p 480 Instrument is a simple and flexible stand-alone solution that eliminates complications associated with manual sample handling.

  • Automate labour-intensive interactions—allows technicians to focus on more sophisticated activities
  • Minimise opportunity for sample contamination—increases sample reproducibility and process reliability


Removes caps from primary tubes for testing on the cobas® 4800, 6800 or 8800 Systems

Up to 1,536 samples in an 8-hour shift

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Recaps sample vials with new caps to avoid contamination

Up to 1,536 samples in an 8-hour shift


Aliquots configurable volumes from PreservCyt®, SurePath and cobas® PCR Cell Collection Media primary vials into barcode matched secondary tubes

Up to 672 samples in an 8-hour shift

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reagent addition & heating

Reagent addition & heating

Addition of cobas® Sample Prep Buffer and incubation of specimens collected in SurePathmedium to reverse cross-linking and free nucleic acids for testing1,*

Up to 1,536 samples in an 8-hour shift

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*Automation of the SurePath™ pre-treatment procedure with the cobas p 480 Instrument has not been reviewed by FDA and is not approved in the US.

Learn more about the cross-linking process

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Advanced contamination prevention

The cobas 480 Instrument uses a combination of physical, software, and process-based controls to ensure confidence in sample and result integrity.

Advanced liquid-handling technologies

Compressed O-Ring Expansion (CO-RE) Tip Technology

Reduces aerosol production during tip ejection


Total Aspirate and Dispense Monitoring (TADM)

Real-time monitoring of aspiration and dispensing steps

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Anti-droplet Control (ADC)

Continually monitors pipetting channel pressure and adjusts in real time


Achieve process reliability and full data tracking with the intuitive software and process controls of the cobas p 480 Instrument. Featuring easy-to-use software and a simple and intuitive interface, you can keep your pre-analytic processes under complete control.

cobas P 480 processes

Pre-analytic efficiency

The cobas p 480 Instrument improves laboratory efficiency by allowing valuable technician time to be used more productively, eliminating repetitive, manual sample handling, improving workflow and reducing risk of contamination, human error and workplace injury.

Registration status


Package inserts

Access package inserts through your country’s Roche Diagnostics Website.


  1. Kiernan JA. Preservation and retrieval of antigens for immunohistochemistry—methods and mechanisms. Part 2: Retrieving masked antigens. Accessed December 20, 2016. The Cutting Edge. 2005:5-11.

Related systems

Product image for cobas® 4800 System image

cobas® 4800 System

Highly efficient, flexible workflows and a consolidated assay menu deliver confidence with every result. Automated PCR setup and analysis help make the most of your resources and reduce error.