NimbleDesign Software

Overview

NimbleDesign is a free online tool that enables you to quickly and easily design custom SeqCap® EZ Choice or HEAT-Seq® Choice Designs. The NimbleDesign software uses our empirically optimized probe database and design process, derived from years of design experience, for proven probe selection. This web-based application provides you 24/7 access with easy setup in designing your probe sets for human and non-human research applications.

Benefits of NimbleDesign Software

Intuitive User Interface from Start to Finish: Follow clear, simple instructions to create one design or many in parallel for your target region of choice
Flexible Input: Choose from a broad list of commonly used gene identifiers to retrieve annotation for your review. In addition to coordinate entry, input a long list of gene names or look up genes via the search tool to add target regions for your design
Comprehensive Design Features: Design to target human or mouse genomes with the ability to create or modify DNA or RNA designs

Product Highlights

Rapid turnaround time for custom designs

Easy step-by-step instructions for selecting your genomic targets
Ability to develop multiple designs in parallel for quick review and selection of the best design within a few hours

Convenience with an easy workflow

24/7 access with easy setup for creating and approving your custom target enrichment designs

Discovery of more variants through our proven industry-leading design algorithm*

Superior capture efficiency leveraging years of design informatics expertise and 2.1M overlapping probes to ensure the highest uniform coverage

Rapid configuration of custom molecular inversion probe (MIP) panels

Data-driven HEAT-Seq Choice databases to create custom panels of up to 20,000 probes for human genetics research applications

View performance data showing higher coverage of target regions using NimbleDesign compared to a competitor software.

Design comparison between SeqCap EZ Choice Enrichment System and Competitor A Design Software. A 3.51Mb region on Chromosome 18 was targeted to compare probe coverage across design platforms. NimbleDesign probes covered 79.3% of the target region (2.79 Mb of target) compared to a coverage of 50.2% (1.77 Mb of target) by Competitor A design software. Note: Probe design used standard design parameters for both NimbleDesign and Competitor A software. Coordinate files from each design was uploaded to SignalMap software to obtain coverage file illustrated above. About 1.05 Mb of coverage space was unique to the NimbleDesign platform that was not covered by the Competitor A software.

NimbleDesign is compatible with the following products:

*Clark M, et al. Nat. Biotech. 2011. Performance comparison of exome DNA sequencing technologies.

*Data on file.

Research use only. Not for use with diagnostic procedures.
SEQCAP and HEATSEQ are trademarks of Roche.

Overview

The NimbleDesign® free online tool enables you to quickly and easily design custom SeqCap® EZ Prime Choice or HEAT-Seq® Choice Designs. The NimbleDesign software uses our empirically optimized probe database and design process, derived from years of design experience, for proven probe selection. This web-based application provides you 24/7 access with easy setup in designing your probe sets for human and non-human research applications.

Benefits of NimbleDesign Software

Intuitive User Interface from Start to Finish: Follow clear, simple instructions to create one design or many in parallel for your target region of choice
Flexible Input: Choose from a broad list of commonly used gene identifiers to retrieve annotation for your review. In addition to coordinate entry, input a long list of gene names or look up genes via the search tool to add target regions for your design
Comprehensive Design Features: Design to target human, rat, mouse, and cattle genomes with the ability to create or modify DNA or RNA designs

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Product Highlights

Discovery of more variants through our proven industry-leading design algorithm*

Superior capture efficiency leveraging years of design informatics expertise and 2.1M overlapping probes to ensure the highest uniform coverage

Rapid turnaround time for custom designs

Easy step-by-step instructions for selecting your genomic targets
Ability to develop multiple designs in parallel for quick review and selection of the best design within a few hours

Convenience with an easy workflow

24/7 access with easy setup for creating and approving your custom target enrichment designs

View data demonstrating 20% increase in of target region capture using SeqCap EZ Choice Enrichment Kits compared to a competitor kit.

Capture more target regions. Design comparison of SeqCap EZ Choice Probes Library versus Agilent SureSelect Kit for a 500 kb target on chr11 (61-61.5 Mb). SeqCap EZ Choice Probes target 20% more of the target region (362 kb vs. 256 kb), as illustrated by an increase in number and coverage black horizontal bars, denoting more coverage of the target regions. Note: The SeqCap EZ Choice design was created using Roche's most stringent standard design parameters; the Supplier A's design was created using their online design tool using it's most stringent design parameters.

Multiple supported species types for DNA, RNA and Epigenetics

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NimbleDesign software is compatible with the following products:

*Data on file.

Research Use Only. Not for use in diagnostic procedures.
SEQCAP, NIMBLEDESIGN and HEATSEQ are trademarks of Roche.

Research use only. Not for use with diagnostic procedures.
SEQCAP and HEATSEQ are trademarks of Roche.

Technical Documents

Instructions for product use and other product-related technical documents

Research use only. Not for use with diagnostic procedures.
SEQCAP and HEATSEQ are trademarks of Roche.