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SeqCap EZ choiceXL

Overview

SeqCap® EZ Choice XL Probes allow for enrichment of genomic regions of interest from 7 Mb to 200 Mb for human resequencing studies with an automation-friendly workflow. SeqCap® EZ Choice Probes are replaced by SeqCap® EZ Choice Prime Probes, which provide improved GC coverage compared to EZ Choice Probes.

Benefits of SeqCap EZ Choice XL Probes
  • Capture from 7 Mb up to 200 Mb custom regions with a single design utilizing up to 2.1 million probes
  • Achieve uniform and high performance capture and save on sequencing costs.
  • Capture more target regions to identify more variants compared to other enrichment methods*
  • Obtain higher coverage of target regions with our advanced repeat masking methods
  • Combine with KAPA's library preparation products to create the HyperCap Workflow v2.0 for a fully integrated sample preparation solution.
Product Highlights

Capture of more target regions compared to competitor kits

SeqCapEZ_Choice_XL_Figure1.png

Design comparison between SeqCap EZ Probes and Competitor A Design Software. A 3.51Mb region on Chromosome 18 was targeted to compare probe coverage across design platforms. Roche NimbleDesign probes covered 79.3% of the target region (2.79 Mb of target) compared to a coverage of 50.2% (1.77 Mb of target) by Competitor A design software. Note: Probe design used standard design parameters for both NimbleDesign and Competitor A software. Coordinate files from each design was uploaded to SignalMap software to obtain coverage file illustrated above. About 1.05 Mb of coverage space was unique to the NimbleDesign platform that was not covered by the Competitor A software.

SeqCapEZ_Choice_XL_Figure1.png

Design comparison between SeqCap EZ Probes and Competitor A Design Software. A 3.51Mb region on Chromosome 18 was targeted to compare probe coverage across design platforms. Roche NimbleDesign probes covered 79.3% of the target region (2.79 Mb of target) compared to a coverage of 50.2% (1.77 Mb of target) by Competitor A design software. Note: Probe design used standard design parameters for both NimbleDesign and Competitor A software. Coordinate files from each design was uploaded to SignalMap software to obtain coverage file illustrated above. About 1.05 Mb of coverage space was unique to the NimbleDesign platform that was not covered by the Competitor A software.

Design your own targets

NimbleDesign, our free online tool, enables you to quickly and easily design custom SeqCap EZ Prime Choice, SeqCap EZ Prime Developer Probes, SeqCap EZ Prime Choice XL or HEAT-Seq® Choice Designs for human and non-human research applications. Learn more about the NimbleDesign software for custom target enrichment designs.

  *Data on file.

Research Use Only. Not for use in diagnostic procedures.
SEQCAP, HEAT-SEQ and NIMBLEDESIGN are trademarks of Roche. All other product names and trademarks are the property of their respective owners.


Technical Documents

Instructions for product use and other product-related technical documents

Research Use Only. Not for use in diagnostic procedures.
SEQCAP is a trademark of Roche. All other product names and trademarks are the property of their respective owners.

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Description Target Regions Catalog Number
 Pack Size How to Buy
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06740260001
 4 Reactions Contact Us
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06266363001
 12 Reactions
 Contact Us
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06266371001
 24 Reactions
 Contact Us
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06266380001
 48 Reactions
 Contact Us
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06266398001
 96 Reactions
 Contact Us
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06266401001
 384 Reactions
 Contact Us
SeqCap EZ Choice XL
 7Mb-200Mb human genomic regions
 06266517001
 960 Reactions
 Contact Us

Reagents and accessories are available separately.

Research Use Only. Not for use in diagnostic procedures.
SEQCAP is a trademark of Roche. All other product names and trademarks are the property of their respective owners.