CONFIRM anti-CD68 (KP-1) Primary Antibody

CONFIRM anti-CD68 (KP-1) Primary Antibody, tonsil, 120x

This antibody is intended for in vitro diagnostic use.

Ventana Medical Systems' (Ventana®) CONFIRM anti-CD68 (KP-1) Primary Antibody is a mouse monoclonal antibody, class IgG1 kappa. The antibody is intended for qualitative staining in sections of formalin-fixed, paraffin-embedded tissue on a Ventana automated slide stainer. CONFIRM anti-CD68 reacts with a 110 KD intracellular glycoprotein associated with the cell membrane of macrophages and some myeloid elements.1,2,3,4 Unexpected antigen expression or loss of expression may occur, especially in neoplasms. Occasionally stromal elements surrounding heavily stained tissue or cells will show immunoreactivity.

The clinical interpretation of any staining, or the absence of staining, must be complemented by morphological studies and evaluation of proper controls. Evaluation must be made by a qualified pathologist within the context of the patient’s clinical history and other diagnostic tests. Caution: U.S. Federal law restricts this device to sale by or on the order of a physician.

  1. Herman GE, Elfont EA. The taming of immunohistochemistry: the new era of quality control. Biotech Histochem 66(4): 194-199, 1991.
  2. Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol 73(5): 626-32, 1980.
  3. Nadji M, Morales AR. Immunoperoxidase: part 1. The technique and its pitfalls. Lab Med 14: 767, 1983.
  4. Taylor RT, Cote RJ. Immunomicroscopy: A Diagnostic Tool For The Surgical Pathologist, 2nd Edition. W.B. Saunders Company, Philadelphia, 1994.
  5. Sheehan DC, Hrapchak BB. Theory and practice of histotechnology, 2nd Edition. The C.V. Mosby Company, St. Louis, 1980.
  6. College of American Pathologists Laboratory Accreditation Program, Anatomic Pathology Checklist, 2001.
  7. NCCLS. Quality Assurance for Immunocytochemistry: Approved Guideline. NCCLS document MM4-A- (ISBN 1-56238-396-5). NCCLS, 940 West Valley Road, Suite 1400, Wayne, PA 19087-1898 USA, 1999.
  8. Herman GE, Elfont EA. The taming of immunohistochemistry: the new era of quality control. Biotech Histochem 66(4): 194-199, 1991.
  9. Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol 73(5): 626-32, 1980.
  10. Nadji M, Morales AR. Immunoperoxidase: part 1. The technique and its pitfalls. Lab Med 14: 767, 1983.
  11. Roche PC, Hsi ED. Immunohistochemistry-Principles and Advances. Manual of Clinical Laboratory Immunology, 6th edition. (NR Rose Ed.) ASM Press, 2002.