This antibody is intended for in vitro diagnostic use.
Ventana Medical Systems' (Ventana) CONFIRM anti-Keratin (AE3) is a mouse monoclonal antibody (IgG1, kappa) directed against basic cytokeratins of h 65-67, 64, 59, 56, and 52 kD.1,2,3,4
Unexpected antigen expression or loss of expression may occur, especially in neoplasms. Occasionally stromal elements surrounding heavily stained tissue or cells will show immunoreactivity.
The clinical interpretation of any staining, or the absence of staining, must be complemented by morphological studies and evaluation of proper controls. Evaluation must be made by a qualified pathologist within the context of the patient’s clinical history and other diagnostic tests. Caution: U.S. Federal law restricts this device to sale by or on the order of a physician.