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cobas^® KRAS Mutation Test

Identifies mutations in codons 12, 13 and 61 of the KRAS gene

The cobas^® KRAS Mutation Test offers broad mutation coverage of KRAS codons 12, 13 and 61 to identify colorectal cancer patients who are not likely to respond to anti-EGFR monoclonal antibody therapies.

Features and benefits

The cobas^® KRAS Mutation Test detects major mutations in codons 12, 13 and 61 from colorectal cancer patients
In formalin-fixed, paraffin-embedded tissue (FFPET), the cobas^® KRAS Mutation Test can detect <5% mutant sequence copies in a background of wild-type DNA
Robust, reliable KRAS test results can be obtained from a single, 5µm FFPET section with >10% tumor content using the cobas^® KRAS Mutation Test
The test can be performed in <8 hours so results can be reported to the treating physician within a few days from laboratory receipt of specimen
Liquid, ready-to-use reagents increase laboratory efficiency
Automated result interpretation and test reporting provides consistent, objective and reproducible results from laboratory to laboratory

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Intended use

CE-IVD

The cobas^® KRAS Mutation Test, for use with the cobas^® 4800 System, is a real-time PCR test intended for the identification of mutations in codons 12, 13 and 61 of the KRAS gene in DNA derived from formalin-fixed paraffin-embedded human colorectal and non-small cell lung cancer tissues.