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cobas® Cdiff Test",
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cobas® 4800 System",
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cobas® 4800 CT/NG Test",
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MMx 1: channel 1: BRAF V600E/E2/D
BRAF V600K*
channel 2: NRAS G12
channel 3: BRAF Exon 11
channel 4: BRAF Internal Control (exon 17)
MMx 2: channel 1: BRAF V600R
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channel 2: NRAS Q61
channel 3: NRAS A18T
channel 4: NRAS Internal Control (exon 5)
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MMx 3: channel 1: BRAF K601E
channel 2: NRAS G13X
channel 3: NRAS Other Exon 3/4
channel 4: NRAS Internal Control (exon 5)
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MMx 1:
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- channel 2: Q61 E/Hc/Hat/K/L/P/R
- channel 3: none
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MMx 2:
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- channel 2: K117 Nc/Nt
- channel 3: A59 E/G/S/Tc
- channel 4: KRAS Internal Control
MMx 3:
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- channel 2: A146 P/T/V
- channel 3: Q61Hc
- channel 4: KRAS Internal Control
The IC for KRAS covers a region of the 3' UTR that is reported to be absent of somatic mutations
Result reporting for channels that detect more than one mutation will not identify each specific mutation. For example, a G12R mutation will be reported as G12X.
For more specific information on which specific mutation are included in each channel and Master Mix, please consult the Instructions for Use (available in the \"download\" section)",
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cobas p 480 instrument is a stand-alone general purpose laboratory instrument to minimize repetitive manual tasks associated with specimen handling. This instrument is intended to perform pre-analytics processing such as decapping and recapping, pipetteand spin-mixing specimens, and aliquoting specimens to secondary vials. Additional hardware components and programing flexibility allow automation of more complex pre-analytic processes including reagent addition and heating.",
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