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cobas® 4800 BRAF V600 Mutasyon Testi

cobas® 4800 BRAD V600 Mutasyon Testi

cobas® 4800 BRAF V600 Mutasyon Testi

Formalinle fikse edilmiş, parafine gömülmüş (FFPET) insan dokusundaki BRAF V600 mutasyonlarını saptayan gerçek zamanlı bir PCR testidir. Melanom tümörlerinde BRAF geninin mutasyon geçirmiş bir formu bulunan hastaların seçilmesine yardımcı olacak şekilde tasarlanmıştır.
Bu test ayrıca papiller tiroid karsinomu (PTC) dokusundaki BRAF V600 mutasyonlarını saptamak için de kullanılabilir.

Özellikler ve avantajlar

  • cobas® 4800 BRAF V600 Mutasyon Testi; melanomada bulunan tüm BRAF mutasyonlarının yaklaşık %90'ını temsil eden BRAF codon 600 mutasyonu V600E'yi ve bazı V600E dışı mutasyonları (V600D, V600E2 ve V600K) saptar1
  • cobas® 4800 BRAF V600 Mutasyon Testi, ilgili önemli klinik çalışmalarda tümörleri BRAF V600 mutasyonu olan hastaları tespit etmek için geliştirilmiştir
  • Formalinle fikse edilmiş, parafine gömülmüş dokularda (FFPET), cobas® 4800 BRAF V600 Mutasyon Testi, ≥%5 mutasyon düzeyindeki V600E mutasyonlarını saptayabilmektedir
  • cobas®  4800 BRAF V600 Mutasyon Testi, numune alındıktan sonra <8 saat içinde gerçekleştirilebilir ve tek bir çalışmada en fazla 94 numune işlenebilir
Kullanım amacı

Kullanım amacı

cobas® 4800 BRAF V600 Mutasyon Testinin kullanım amacı; formalinle fikse edilmiş, parafine gömülmüş insan melanom dokusundan ve papiller tiroid karsinomu (PTC) dokusundan ekstre edilen DNA'da BRAF V600 mutasyonlarını saptamaktır.

Melanom vakalarında, hedefli tedavilerden fayda görmesi beklenen BRAF V600 mutasyonları bulunan hastaların tedavi için tespit edilmesi için kullanıma yöneliktir.

Ruhsat durumu

CE-IVD

İlgili hastalıklar

Referanslar

 

1. COSMIC veritabanı v83 (Kasım 2017)

Bize Ulaşın

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