HPV mRNA Probes

RNA probes for detection of specific HPV mRNA in tissue for use in laboratory developed tests*

HPV mRNA Probes
  • Detects the biologically relevant HPV E6/E7 mRNA markers in morphologic context.
  • HPV mRNA probes available: HPV 6, HPV 11, HPV 16, HPV 18, and HPV 33.
HPV mRNA ISH probes
  • HPV E6 and E7 are biologically relevant markers.
  • Detect E6 and E7 mRNA in formalin-fixed, paraffin-embedded (FFPE) tissue. 
  • Raw material for laboratory developed tests (LDTs)/Analyte Specific Reagent.*
Cell Cycle Control Mechanisms of the HPV Virus
HPV E6 E7 Oncoprotein expression

Figure 1. Two of the early HPV genes encode for the oncoproteins E6 and E7. mRNA transcription in cells indicates active viral processes. Overexpression of E6 and E7 mRNA precedes transformation of cells. In persistent high risk HPV infections, E6 and E7 oncoproteins disrupt the p53 and retinoblastoma protein (pRb) cell cycle control mechanisms respectively.


Five probe options are available, each is an HPV genotype-specific DNP-labeled ISH probe designed to bind to the respective HPV E6/E7 mRNA transcript.

Product Name


HPV 6 mRNA Probe

760-1239 07658877001

HPV 11 mRNA Probe

760-1240 07658885001

HPV 16 mRNA Probe

760-1236 07658834001

HPV 18 mRNA Probe

760-1237 07658842001

HPV 33 mRNA Probe

760-1238 07658869001

For more information

Download the HPV mRNA in situ hybridization (ISH) sales sheet

Visit the Pathology Education Portal to learn more about probe use and interpretation

* Analytical and performance characteristics are not established.