VENTANA PD-L1 (SP142) Assay

Identify non-small cell lung cancer (NSCLC) patients eligible for TECENTRIQ®

Your assay choice matters

Using the right test to determine PD-L1 status for immunotherapy options is important, and the VENTANA PD-L1 (SP142) Assay is an FDA-approved test for TECENTRIQ®. This innovative assay is the first to evaluate patient PD-L1 expression using both tumor cell (TC) and tumor-infiltrating immune cell (IC) staining. Determining a patient's PD-L1 expression level can give insight to the overall survival that may be achieved from TECENTRIQ®.

The VENTANA PD-L1 (SP142) Assay:

FDA approved to identify NSCLC patient treatment benefit from TECENTRIQ®
Novel scoring algorithm using PD-L1 staining in both TC and IC
Designed to enhance visual contrast of immune cell staining within the tumor microenvironment

The PD-L1 (SP142) Assay gives you the confidence to guide immunotherapy decisions in NSCLC.

*All randomized patients in a NSCLC phase Ill study observed benefit from TECENTRIQ® regardless of PD-L1 status.

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Staining characteristics in non-small cell lung cancer (NSCLC)

General Guidance

A patient’s NSCLC tissue stained with the VENTANA PD-L1 (SP142) Assay is evaluated for tumor cells (TC) and/or tumor-infiltrating immune cells (IC) staining. TC are scored as the proportion of viable tumor cells showing PD-L1 membrane staining of any intensity. IC are scored as the proportion of tumor area that is occupied by PD-L1 staining IC of any intensity.

Figure 1: Positive NSCLC tissue stained with VENTANA PD-L1 (SP142) Assay (≥ 50% TC or ≥ 10% IC). IC often show dark brown punctate or linear staining, which is the predominant IC staining pattern observed in the majority of tissues. IC staining is often seen as aggregates either in intratumoral or peritumoral stroma (tumor-stroma interface) or in both locations. TC often exhibit moderate to strong, partial or complete circumferential membrane staining with or without cytoplasmic component.

Ordering Information

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Product name	Catlog number	Ordering code	Quantity
VENTANA PD-L1 (SP142) Assay Tissue Control: Tonsil Species: Rabbit Localization: Membranous and/or Cytoplasmic	740-4859	07709374001	50 tests
OptiView DAB IHC Detection Kit	760-700	06396500001	250 tests
OptiView Amplification Kit	860-099	06718663001	250 tests
Rabbit Monoclonal Negative Reagent Control Ig	790-4795	06683380001	250 tests

References

TECENTRIQ® Summary of Product Characteristics.
Ventana Medical Systems Inc. VENTANA PD-L1 (SP142) Assay Package Insert.