cobas h 232 POC system

cobas h 232 – POC System

The cobas h 232 system enables confident on-the-spot diagnosis and management of patients presenting with signs and symptoms of cardiovascular disease

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How to Use
Ordering Package
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Test multiple biomarkers

Confidently test for markers and make a differential diagnosis^1-5.

NT-proBNP Exclude heart failure (HF) and identify patients in need of further cardiac investigation^2,7
D-Dimer Rule out pulmonary embolism (PE) and deep vein thrombosis (DVT)^1,6
Cardiac Troponin T Early rule in acute myocardial infarction (AMI) and help identify patients with elevated mortality risk^3,8,9
CK-MB Aid in the diagnosis of AMI and detection of reinfarction^4,8
Myoglobin Support in the early diagnosis of AMI^5,10

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Accurate result

Result standardized with Roche central laboratory cobas^® immunochemistry platforms¹¹

cobas h 232 POC system

1 heparinised tube

Immunochemistry platforms

Fast-to-result

Result obtained in 8-12 minutes¹²
(Time varies with the assay used)

Easy to use

Small portable design

No maintenance
No calibration
No sample preparation

How to Use

Quick Guide

Ready to use

No sample preparation¹²
No calibration (automatic)¹²
No warm up¹²

Test in 3 steps

1.Insert a Test Strip

2. Apply Sample

of 150ul heparinised whole blood using the Roche cardiac pipette

3. Read Results

3 Items needed for running a test:

1. Test strip (e.g NTproBNP)
2. Heparinized whole blood (sample)
3. 150ul pipette (to apply sample)

Ordering Package

Material Number	Description
04901142190	cobas h232 instrument with scanner
05533643190	proBNP test strips (10 tests/box)
04880668190	Roche CARDIAC IQC
11622889190	Roche CARDIAC Pipettes, 20 disposable syringes (150 μL)

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The story of Paul and the management of his chronic heart failure

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Enquiry/ Ask for a Quote

Roche Diagnostics (Hong Kong) Limited

Address:	Level 17, Metroplaza, Tower 1,223 Hing Fong Road, Kwai Chung, Hong Kong
Phone:	+852 2481 3387
Fax:	+852 2418 0728
E-mail	[email protected]

References:

Roche CARDIAC D-Dimer-Method Sheet-package insert.
Roche CARDIAC proBNP-Method Sheet-package insert.
Roche CARDIAC POC Troponin T-Method Sheet-package insert.
Roche CARDIAC CK-MB-Method Sheet-package insert.
Roche CARDIAC M-Method Sheet-package insert.
Konstantinides, S. et al. (2014). Eur Heart J 35, 3033-3080.
Ponikowski, P. et al. (2016). Eur J Heart Fail 18(8), 891-975.
Roffi , M. et al. (2015). Eur Heart J 37(3), 267-315.
Stengaard, C. et al. (2013). American J Cardiol 112(9), 1361-1366.
Achar, S.A. et al. (2005). Am Fam Physician 72(1), 119-126.
Bertsch, T. et al. (2010). Clin Lab. 56(1-2), 37-49. ; Jungbauer, C. et al. (2017). Cli Lab 63(4), 633-645.
Roche (2016). cobas h 232 POC system Operator’s Manual, Version 6.0.

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What is NT-proBNP?

NT-proBNP has been used in HF for over 15 years, and is considered the gold standard for testing in HF disease management.¹³

NT-proBNP also has an emerging and impactful use in T2DM patients, who are at an increased risk of CVD complications.^14-17

Natriuretic peptides, including NT-proBNP, are produced within cardiomyocytes in response to stress, and are released after clinical triggers.¹²

Use as an initial diagnostic test

In association with clinical evaluation,* NT-proBNP can support decision-making in HF diagnosis in acute and non-acute Settings.

Exclude HF and avoid unnecessary echocardiography^6-8
Identify patients with high probability of having HF and need further investigation²
In primary care, identify patients who need referral to the specialist^6-8

Interpretation of NT-proBNP results in patients presenting

in non-acute setting^1-5

Roche NT-proBNP

<125pg/mL HF unlikely,

consider other diagnoses

Roche NT-proBNP

>125pg/mL

HF likely,
perform

echocardiography to
confirm the diagnosis
of HF

Interpretation of NT-proBNP results in patients presenting

in non-acute setting^9-13

Roche NT-proBNP

<125pg/mL HF unlikely,

consider other diagnoses

Roche NT-proBNP

>125pg/mL

HF likely,
perform

echocardiography to
confirm the diagnosis
of HF

Use as out patient monitoring

NT-proBNP can be used to monitor disease progression or patient improvement in out-patient setting

Monitoring NT-proBNP levels helps to manage HF well over the long term, regardless of symptoms or medication being taken, in particular angiotensin receptor-neprilysininhibitors (ARNis)⁹.

ⓘKnow more about NT-proBNP

References:

Rutten et al. https://ipccs.org/2017/12/10/epccs-practical-guidance-on-heart-failurediagnosis-and-management-in-primary-care/ (Accessed May 24 2022).
Ponikowski P, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016;18(8):891-975. doi:10.1002/ejhf.592.
Taylor CJ, et al. Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study. Br J Gen Pract. 2017;67(655):e94-e102. doi:10.3399/bjgp16X688393.
Taylor et al. (2017). Efficacy and Mechanism Evaluation, No. 4.3. National Institute for Health Research. ISSN 2050-4365.
Hildebrandt P, Collinson PO, Doughty RN, et al. Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. Eur Heart J. 2010;31(15):1881-1889. oi:10.1093/eurheartj/ehq163.
Taylor, C.J. et al. (2017). Br J Gen Pract. 67(655), e94-e102.
Taylor, C.J. et al. (2017). Effi cacy and Mechanism Evaluation, No. 4.3. National Institute for Health. Research. ISSN 2050-4365. [Accessed September 2018].
British Heart Foundation and the All-Party Parliamentary Group on Heart Disease (2016). Focus on Heart Failure. Report accessible on https://www.bhf.org.uk/get-involved/campaigning/inquiry-intoliving-with-heart-failure [Accessed September 2018].
Januzzi, J.L. et al. (2016). Clin Chem 62(5), 663-665.
Masson, S. et al. (2008). J Am Coll Cardiol 52, 997-1000.
Januzzi (2012). Arch Cardiovasc Dis. 105(1), 40-50
Weber M, Hamm C. Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart. 2006;92(6):843-849. doi:10.1136/hrt.2005.071233.
McKie PM, Burnett JC Jr. NT-proBNP: The Gold Standard Biomarker in Heart Failure. J Am Coll Cardiol. 2016;68(22):2437-2439. doi:10.1016/j.jacc.2016.10.001.
Huelsmann M, et al. NT-proBNP has a high negative predictive value to rule-out short-term cardiovascular events in patients with diabetes mellitus. Eur Heart J. 2008;29(18):2259-2264. doi:10.1093/eurheartj/ehn334.
Huelsmann M, et al. PONTIAC (NT-proBNP selected prevention of cardiac events in a population of diabetic patients without a history of cardiac disease): a prospective randomized controlled trial. J Am Coll Cardiol. 2013;62(15):1365-1372. doi:10.1016/j.jacc.2013.05.069.
Scirica BM, et al. Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial [published correction appears in Circulation. 2015 Oct 13;132(15):e198]. Circulation. 2014;130(18):1579-1588. doi:10.1161/ CIRCULATIONAHA.114.010389.
Einarson TR, et al. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017. Cardiovasc Diabetol. 2018;17(1):83. Published 2018 Jun 8. doi:10.1186/s12933-018-0728-6.

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