Monitoring Roche NT-proBNP in heart failure patients can provide powerful prognostic information

Gain insights regarding disease progression by using Roche NT-proBNP to monitor heart failure patients.


The trend in NT-proBNP levels in heart failure (HF) patients over time gives valuable prognostic information.1,2 The use of Roche NT-proBNP test to monitor patients helps to: 

  • Identify patients that appear to be doing well symptomatically, yet whose underlying disease is still not in contol3
  • Avoid prescribing inertia and ensure your patients' treatment is effective4


Make the right choice in biomarker at every stage of care with Roche NT-proBNP. 


In the era of angiotensin receptor-neprilysin inhibitor (ARNi) therapy, the choice in biomarker for HF patients becomes increasingly important. Active B-type natriuretic peptide (BNP) is a neprilysin substrate, making BNP an unsuitable biomarker in HF patients treated with sacubitril-valsartan.4-9 The use of Roche NT-proBNP can help support your clinical decisions to provide the best patient care - especially when a patient's medication regimen is unknown at the time of presenting. 


Trend in Roche NT-proBNP concentration over time can give important prognostic information.1,2

Roche NT-proBNP prognosticator chart
  • Elevated Roche NT-proBNP values are strongly predictive of adverse outcomes and rising values identify a rising risk8,10,11
  • Significant lowering of Roche NT-proBNP is associated with better prognosis and improved clinical outcomes8,10-13
  • In PARADIGM-HF, changes in Roche NT-proBNP over the course of HF provided important prognostic information and can help to identify patients at risk of hospitalization for HF and mortality1,2,8
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NT-proBNP: N-terminal prohormone of brain natriuretic peptide



  1. Masson et al. (2008). J Am Coll Cardiol. 52, 997-100
  2. Januzzi (2012). Arch Cardiovasc Dis. 105, 40-50
  3. Pellicori et al. (2017). Eur J Heart Failure. 19, 768-778 
  4. Yancy et al. (2017). Circulation. 136, e137 – e161
  5. Entresto. Summary of Product Characteristics. EMA approval. [Accessed on January 23th, 2018]
  6. Januzzi (2016). Clin Chem. 62(5), 663-665
  7. Entresto, Switzerland approval. Fachinformation des Arzneimittel-Kompendium der Schweiz®, [Accessed on January 24th, 2018]
  8. Zile et al (2016). J Am Coll Cardiol. 68, 2425-2436
  9. McKie and Burnett (2016). J Am Coll Cardiol. 62, 2437-2439
  10. Chiong et al. (2010). Heart Fail Rev. 15, 275-291
  11. Weiner et al. (2012). Eur J Heart Fail. 15, 342-351
  12. Gaggin et al. (2013). Congest Heart Fail. 19, 135-42
  13. Deberadinis and Januzzi. (2012). Curr Opin Cardiol. 27, 661-668