The cobas® 4800 BRAF V600 Mutation Test is a real-time PCR assay that detects BRAF V600 mutations in formalin-fixed, paraffin-embedded (FFPET) human tissue. It is designed to help select patients for treatment with vemurafenib alone or in combination with cobimetinib, to treat patients whose melanoma tumors harbor a mutated form of the BRAF gene.
1. Catalogue of Somatic Mutations in Cancer (COSMIC), 2017, v.83. http://www.sanger.ac.uk/genetics/CGP/cosmic.