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• pH
• Krevní plyny (BG): PO₂, PCO₂
• Elektrolyty (ISE): Na⁺, K⁺, Cl^- , iCa²⁺
• Hematokrit (Hct)
• Metabolity (MSS): glukóza, laktát, močovina/BUN (pouze online verze)
• Celkový hemoglobin (tHb)
• Saturace kyslíkem (SO₂)
• Deriváty hemoglobinu COOX (O₂Hb, HHb, COHb, MetHb)
• Bilirubin (neonatální)
   

Kromě toho systém cobas b 221 vypočítává odvozené parametry.

Následující parametry lze měřit v plné krvi, séru nebo plazmě:

• pH
• Krevní plyny (BG): PO₂, PCO₂
• Elektrolyty (ISE): Na⁺, K⁺, Cl^- , iCa²⁺
• Hematokrit (Hct)
• Metabolity (MSS): Glu, Lac, Urea/BUN
• Celkový hemoglobin (tHb)
• Saturace kyslíkem (SO₂)
• Deriváty hemoglobinu COOX (O₂Hb, HHb, COHb, MetHb)
• Bilirubin (neonatální)

V pleurální tekutině lze měřit následující parametr:

• pH

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Konfigurace pro  systém cobas b 221<2> systém: BG, pH, COOX, Bili", "Country": "XG", "Code": "Product Description", "Name": "Product Description" } ] } } ] }