ResistancePlus^® GC

Antimicrobial resistance is on the rise. Neisseria gonorrhea (NG) — also known as Gonococcus (GC) — already developed resistance to multiple classes of antibiotics and is classified as “urgent threat” by the Centers for Disease Control and Prevention.¹ Today, advances in testing can enable  more accurate treatment, and aims to help healthcare professionals preserve last-line antibiotics for future use.

Through a partnership with SpeeDx, a developer of innovative molecular diagnostic solutions, Roche is ushering in a new era of resistance-focused diagnostics.

ResistancePlus® GC features and benefits

Easy adoption: Fits into any laboratory workflow, providing both detection as well as ciprofloxacin susceptibility in a single test

Improved patient pathway: Delivers rapid resistance data, reducing the need for injectable antibiotics while freeing-up clinical staff

Antimicrobial stewardship: Informs a patient’s treatment pathway, ensuring the most appropriate antimicrobial is used for front-line therapy

Testing compliance: Meets current and emerging International, European and Australian guideline recommendations

Platform compatibility: Validated to work on a number of extraction  platforms, with amplification/detection on the LightCycler^® 480 Instrument II and the cobas z 480 Analyzer

Inside PlexPCR^® Technology

PlexZyme^® technology offers high performance and reliable qPCR detection.

During PlexPCR^®, primers amplify target nucleic acid sequences and produce amplicons, which serve as a template for PlexZyme^® formation. Once the partzymes have assembled into PlexZyme^® enzymes, universal probes bind and enzymatic cleavage of the probes between fluorophore and quencher dye pairs generates fluorescence. Changes in fluorescence allow detection and/or quantification of the target nucleic acid in real time.

PlexPrime^® is a novel method for nucleic acid amplification that creates amplicons, which are distinctly different from the parent sequence. The combination of PlexPrime^® and PlexPrime^® technology enables multiplex mutation detection with high sensitivity and specificity.³

The ResistancePlus^® GC kit is a qualitative real-time PCR assay for the detection of Neisseria gonorrhoeae and the gyrA S91 wild-type and S91F mutant markers that are associated with susceptibility or resistance to ciprofloxacin. The ResistancePlus^® GC kit can be used with the specimen types listed in the Instructions for Use (IFU).

Registration status: CE-IVD, not yet available in the U.S.