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Elecsys® β-Amyloid(1-42) CSF II

Robust and accurate biomarker tests to solve clinical questions

Elecsys® β-Amyloid(1-42) CSF II

Robust and accurate biomarker tests to solve clinical questions

 

Elecsys® β-Amyloid(1-42) CSF II (AB42 2) is an in vitro diagnostic immunoassay intended for the quantitative determination of the β-Amyloid(1-42) protein concentration in human cerebrospinal fluid (CSF).1

Elecsys® AB42 2 assay is part of the Elecsys® AD portfolio, along with Elecsys® Phospho-Tau (181P) CSF (pTau) and Elecsys® Total-Tau CSF (tTau) immunoassays.1

Elecsys® AD CSF assays can detect amyloid positivity, enhancing diagnostic accuracy and physician confidence.2,3

Elecsys® AD CSF assays enable timely intervention by identifying patients with MCI at risk of progression to AD.1,3

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The Power of Elecsys® in Alzheimer’s disease

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    References

     

    1. Elecsys® Method Sheet: ms_08821941500V1.0, ms_08821909500V1.0, ms_08846715500V1.0, ms_08846693500V1.0,  ms_08846634500V1.0, ms_08846685500V1.0
    2. Rabinovici, G.D. et al. (2019). Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. JAMA 321(13), 1286-1294.
    3. Hansson, O. et al. (2018). CSF biomarkers of Alzheimer’s disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts. Alzheimers Dement 14(11), 1470-1481

    Elecsys® β-Amyloid(1-42) CSF II

    • Testing time

      18 minutes

    • Test principle

      Two-step sandwich 

    • Calibration

      2-point

    • Sample material

      Cerebrospinal Fluid (CSF)

    • Sample volume

      30 µL - cobas e 801 module and cobas e 402 module 

      50 µL - cobas e 411 analyzer and cobas e 601/602 modules

    • LoB (Limit of Blank)

      50 pg/mL

    • LoD (Limit of Detection)

      100 pg/mL

    • LoQ (Limit of Quantitation)

      150 pg/mL

    • Measuring range

      150 – 2,500 pg/mL

    • Reagent onboard-stability

      16 days - cobas e 801 module and cobas e 402 module

      28 weeks - cobas e 411 analyzer and cobas e 601/602 modules
    Elecsys® Total -Tau CSF
    Elecsys® Total -Tau CSF
    Elecsys® Phospho-Tau (181P) CSF
    Elecsys® Phospho-Tau (181P) CSF