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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.3 C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.3,6 C4d can be a useful tool for indicating acute renal allograft rejection.1-6

1. Jianghua C, et al. C4d as a significant predictor for humoral rejection in renal allografts. Clin Transplant. 2005; 19:785-91.
2. Kayler LK, et al. Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d. Transplantation. 2008; 85:813-20.
3. Ranjan P, et al. The role of C4d immunostaining in the evaluation of the causes of renal allograft dysfunction. Nephrol Dial Transplant .2008; 23:1735-41.
4. Nadasdy GM, et al. Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies. Hum Pathol. 2005; 36:1178-85.
5. Seemayer CA, et al. C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques. Nephrol Dial Transplant. 2007; 22:568-76.
6. Bouron-Dal Soglio D, et al. An immunohistochemical evaluation of C4d deposition in pediatric inflammatory liver diseases. Hum Pathol. 2008; 39:1103-10.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Intended Use", "Value": "Le C4d (SP91) Rabbit Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine C4d dans les tissus humains fixés au formol et enrobés à la paraffine, colorés par immunohistochimie (IHC) qualitative sur les instruments BenchMark IHC/ISH. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Principle", "Value": "anti-C4d (SP91) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specifi c temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le C4d (SP91) Rabbit Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine C4d dans les tissus humains fixés au formol et enrobés à la paraffine, colorés par immunohistochimie (IHC) qualitative sur les instruments BenchMark IHC/ISH. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

anti-C4d (SP91) Rabbit Monoclonal Primary Antibody

IVD For in vitro diagnostic use.
anti-C4d (SP91) Rabbit Monoclonal Primary Antibody

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Detailed Specifications

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