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"Name": "Storage Conditions (Product)",
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"Name": "Background Information",
"Value": "Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.
1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.
3 C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.
3,6 C4d can be a useful tool for indicating acute renal allograft rejection.
1-61. Jianghua C, et al. C4d as a significant predictor for humoral rejection in renal allografts. Clin Transplant. 2005; 19:785-91.
2. Kayler LK, et al. Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d. Transplantation. 2008; 85:813-20.
3. Ranjan P, et al. The role of C4d immunostaining in the evaluation of the causes of renal allograft dysfunction. Nephrol Dial Transplant .2008; 23:1735-41.
4. Nadasdy GM, et al. Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies. Hum Pathol. 2005; 36:1178-85.
5. Seemayer CA, et al. C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques. Nephrol Dial Transplant. 2007; 22:568-76.
6. Bouron-Dal Soglio D, et al. An immunohistochemical evaluation of C4d deposition in pediatric inflammatory liver diseases. Hum Pathol. 2008; 39:1103-10.",
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