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{ "IdentifierofStructureSystem": "OWP_Family", "NameofStructureSystem": "Product Families", "StructureNodeID": "080", "StructureGroupPath": "BenchMark", "StructureGroupName": "BenchMark", "StructureNodeStatus": "Active" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Storage Conditions (Product)", "Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "VENTANA anti-Cyclin D1 (SP4-R) antibody contains sufficient reagent for 50 tests.

One 5 mL dispenser of VENTANA anti-Cyclin D1 (SP4-R) antibody contains approximately 0.5 μg of a rabbit monoclonal antibody.

The antibody is diluted in Tris-HCl with carrier protein and 0.10% ProClin 300 as a preservative.

Specific antibody concentration is approximately 0.1 μg/mL. There is no known non-specific antibody reactivity observed in this product.

VENTANA anti-Cyclin D1 (SP4-R) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant material.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le VENTANA anti-Cyclin D1 (SP4-R) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la cycline D1 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour être utilisé en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "VENTANA anti-Cyclin D1 (SP4-R) Rabbit Monoclonal Primary Antibody (VENTANA anti-Cyclin D1 (SP4-R) antibody) is a rabbit monoclonal antibody produced against the C terminus of a recombinant human cyclin D1 protein. Cyclin D1 is a 36 kDa cell cycle regulatory protein that activates cyclin dependent kinase (CDK) 4 and CDK 6 enzymes.^1,2,3Cyclin D1 is expressed at higher levels during the G1 phase, the G1/S transition, and G2 phase of the cell cycle, but it is expressed at lower levels during the S phase.^1,2,3 Cyclin D1 overexpression or amplification is associated with tumorigenesis and is detected in many cancers including mantle cell lymphoma, breast carcinoma, lung carcinoma, and gastrointestinal neoplasms.^1,2,3Of note, mantle cell lymphoma is genetically characterized by the t(11;14)(q13;q32) translocation that juxtaposes the CCND1 gene to the immunoglobulin heavy chain gene resulting in an overexpression of cyclin D1 protein.^1-5 Detection of cyclin D1 overexpression is often used to distinguish mantle cell lymphoma from chronic lymphocytic leukemia/small lymphocytic lymphoma, which shares many other similar morphological and immunophenotypic features.^5-8 This distinction is important because mantle cell lymphoma is a more aggressive neoplasm.^5-8 In addition to mantle cell lymphoma, a low number of other B-cell lymphoma cases (e.g. plasma cell lymphoma, hairy cell leukemia, diffuse large B-cell lymphoma) express cyclin D1.^4-8
The detection of cyclin D1 by immunohistochemistry (IHC) with the VENTANA anti-Cyclin D1 (SP4-R) antibody may be used to aid in the diagnosis of mantle cell lymphoma. This antibody may be used as part of a panel of IHC studies. The staining pattern is nuclear.

1. Montalto FI, De Amicis F. Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma. Cells. 2020;9(12).
2. Musgrove EA, Caldon CE, Barraclough J, et al. Cyclin D as a Therapeutic Target in Cancer. Nat Rev Cancer. 2011;11(8):558-572.
3. Qie S, Diehl JA. Cyclin D1, Cancer Progression, and Opportunities in Cancer Treatment. J Mol Med (Berl). 2016;94(12):1313-1326.
4. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th Ed. Lyon, France: IARC; 2017.
5. Dabbs DJ. Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, 5th Edition. Amsterdam, Netherlands: Elsevier; 2019.
6. Jain P, Wang M. Mantle Cell Lymphoma: 2019 Update on the Diagnosis, Pathogenesis, Prognostication, and Management. Am J Hematol. 2019;94(6):710-725.
7. Veloza L, Ribera-Cortada I, Campo E. Mantle Cell Lymphoma Pathology Update in the 2016 WHO Classification. Annals of Lymphoma. 2019;3:3-3.
8. Wang W, Medeiros LJ. Utility of Cyclin D1 in the Diagnostic Workup of Hematopoietic Neoplasms: What Can Cyclin D1 Do for Us? Adv Anat Pathol. 2019;26:281–291.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "VENTANA anti-Cyclin D1 (SP4-R) antibody binds to the Cyclin D1 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheets for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le VENTANA anti-Cyclin D1 (SP4-R) Rabbit Monoclonal Primary Antibody est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique de la cycline D1 dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour être utilisé en diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

VENTANA anti-Cyclin D1 (SP4-R) Rabbit Monoclonal Primary Antibody

IVD

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