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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Le Cytokeratin (35betaH11) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter les protéines cytokératine 8 et 18 dans les tissus fixés au formol et enrobés à la paraffine, colorés sur les instruments VENTANA BenchMark IHC/ISH. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD)", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Cytokeratin 8, a member of the Type II family of cytokeratins, is typically expressed in simple epithelium. The dimerization of cytokeratin 8 with cytokeratin 18 (labeled by 35betaH11) in the cytoplasm of simple epithelial cells allows for the formation of an intermediate filament cytoskeletal framework. This structure plays a role in the maintenance of cellular structural integrity and also functions in promoting signal transduction and cellular differentiation processes.¹ Additionally, the presence of cytokeratin 8 has been detected in neoplastic epithelia, including glandular epithelium that can be found in prostate carcinoma.² Positive immunoreactivity with anti-cytokeratin 8 is a useful indicator for the identification of normal and neoplastic epithelial tissues.^2,3

1. Moll R, et al. The human keratins: biology and pathology. Histochem Cell Biol. 2008; 129:705-33.
2. Ljung G, et al. Characterization of residual tumor cells following radical radiation therapy for prostatic adenocarcinoma; immunohistochemical expression of prostate-specific antigen, prostatic acid phosphatase, and cytokeratin 8. Prostate. 1997; 31:91-7.
3. Murata T, et al. The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma. Pathol Res Pract. 1993; 189:888-93.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Principle", "Value": "Cytokeratin (35betaH11) Mouse Monoclonal Antibody (this antibody) may be used as the\nprimary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded\ntissue sections. In general, immunohistochemical staining allows the visualization of antigens\nvia the sequential application of a specific antibody (primary antibody) to the antigen, a\nsecondary antibody (link antibody) to the primary antibody, an enzyme complex and a\nchromogenic substrate with interposed washing steps. The enzymatic activation of the\nchromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and\naid in the differential diagnosis of pathophysiological processes, which may or may not be\nassociated with a particular antigen.\n
\n
\nThis antibody is optimally diluted to be compatible with VENTANA detection kits and\nBenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for\nrecommended staining protocols. Each step in the staining protocol includes incubation for\na precise time at a specific temperature. At the end of each incubation step, the sections are\nrinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound\nmaterial that would hinder the desired reaction in subsequent steps. To minimize evaporation\nof the aqueous reagents from the specimen-containing slide, a coverslip solution is applied\nin the slide stainer. For more detailed information on instrument operation, refer to the\nappropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le Cytokeratin (35betaH11) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter les protéines cytokératine 8 et 18 dans les tissus fixés au formol et enrobés à la paraffine, colorés sur les instruments VENTANA BenchMark IHC/ISH. Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés. Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD)", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }