{
"ProductData": {
"ID": "RTD001194",
"ProductType": "Others",
"BrandName": "VENTANA® anti-E-cadherin (36) Mouse Monoclonal Primary Antibody",
"ProductNameAddition": "",
"RegulatoryDisclaimer1": "For in vitro diagnostic use.",
"DisclaimerGroup1": "IVD",
"RegulatoryDisclaimer2": null,
"DisclaimerGroup2": null,
"RegulatoryDisclaimer3": null,
"SampleType": [
"Formalin-Fixed Paraffin-Embedded Tissue (FFPET)"
],
"LicenseDisclaimers": [
],
"RelatedLinks": "",
"Clone": "36",
"ControlTissue": [
"Ductal Breast Carcinoma"
],
"ISOtypes": "IgG2a/K",
"Species": [
"Mouse"
],
"StainLocalization": [
"Membrane"
],
"ProductNameGlobal": "E-cadherin 36 VENTANA"
},
"ProductImageDetails": {
"ImagePath": "https://pim-media.roche.com/Images/Product_RTD001194_im_en.jpg",
"ImageType": "Image main"
},
"Product2Taxonomy": {
"Product2TaxonomyReferences": [
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeID": "05-0002",
"StructureNodeStatus": "Active",
"NodeName": "IHC Primary Antibodies"
},
{
"StructureSystemIdentifier": "OWP_Family",
"StructureSystemName": "Product Families",
"NodeID": "410",
"StructureNodeStatus": "Active",
"NodeName": "VENTANA"
},
{
"StructureSystemIdentifier": "OWP_Techniques",
"StructureSystemName": "Techniques",
"NodeID": "073-00",
"StructureNodeStatus": "Active",
"NodeName": "Immunohistochemistry (IHC)"
},
{
"StructureSystemIdentifier": "Lab_Type",
"StructureSystemName": "Lab Types",
"NodeID": "080-00",
"StructureNodeStatus": "Active",
"NodeName": "Pathology Lab"
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "19-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Oncology"
},
{
"StructureSystemIdentifier": "Disease_Areas",
"StructureSystemName": "Disease Areas",
"NodeID": "08-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Breast cancer"
},
{
"StructureSystemIdentifier": "Disease_Areas",
"StructureSystemName": "Disease Areas",
"NodeID": "23-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Lung cancer"
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "14-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Gynecology"
},
{
"StructureSystemIdentifier": "Health_Topics",
"StructureSystemName": "Health Topics",
"NodeID": "20-00-00",
"StructureNodeStatus": "Active",
"NodeName": "Pulmonology"
},
{
"StructureSystemIdentifier": "Product_Solutions",
"StructureSystemName": "Product Solutions",
"NodeID": "010",
"StructureNodeStatus": "Active",
"NodeName": "Histopathology"
},
{
"StructureSystemIdentifier": "Applications",
"StructureSystemName": "Applications",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "Pathogens",
"StructureSystemName": "Pathogens",
"NodeID": "99-00-00",
"StructureNodeStatus": "Inactive",
"NodeName": ""
},
{
"StructureSystemIdentifier": "OWP_Product_Types",
"StructureSystemName": "Product Types",
"NodeID": "15-000-00",
"StructureNodeStatus": "Active",
"NodeName": "Primary Antibody"
},
{
"StructureSystemIdentifier": "OWP_Family",
"StructureSystemName": "Product Families",
"NodeID": "080",
"StructureNodeStatus": "Active",
"NodeName": "BenchMark"
},
{
"StructureSystemIdentifier": "Indications",
"StructureSystemName": "Indications",
"NodeID": "107",
"StructureNodeStatus": "Active",
"NodeName": "Women's Health"
}
]
},
"Product2Materials": {
"P2MaterialReferences": [
{
"MaterialNum": "05905290001",
"MaterialDescription": "VENTANA Anti-E Cadherin (36)",
"RegisteredProductName": "VENTANA anti-E-cadherin (36) Mouse Monoclonal Primary Antibody",
"GTIN": "04015630983872",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "790-4497",
"PackSizePIM360": "50 tests",
"PackSizeDescPIM360": "Not Available",
"MaterialAnnotation": "",
"ReadyForUse": "true",
"OrderInformation": ""
}
]
},
"Product2Products": {
"Product2ProductReference": [
{
"ProductID": "INS_2099",
"BrandName": "BenchMark ULTRA",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "2300",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA",
"StructureGroupName": "BenchMark ULTRA",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
},
{
"ProductID": "RTD001185",
"BrandName": "ultraView Universal DAB Detection Kit",
"ProductNameAddition": "",
"ReferenceType": "Reagent",
"Classification": [
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0001",
"StructureGroupPath": "Tissue->IHC Detection Systems",
"StructureGroupName": "IHC Detection Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "20-000-00",
"StructureGroupPath": "Assays Reagents and Strips",
"StructureGroupName": "Assays Reagents and Strips",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "660",
"StructureGroupPath": "ultraView",
"StructureGroupName": "ultraView",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "410",
"StructureGroupPath": "VENTANA",
"StructureGroupName": "VENTANA",
"StructureNodeStatus": "Active"
}
]
},
{
"ProductID": "RTD001173",
"BrandName": "ULTRA Cell Conditioning (ULTRA CC1)",
"ProductNameAddition": "",
"ReferenceType": "Auxilliary",
"Classification": [
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0016",
"StructureGroupPath": "Tissue->ISH Bulk Solutions",
"StructureGroupName": "ISH Bulk Solutions",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0005",
"StructureGroupPath": "Tissue->IHC Bulk Solutions",
"StructureGroupName": "IHC Bulk Solutions",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "999-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "95-000-00",
"StructureGroupPath": "Auxiliaries",
"StructureGroupName": "Auxiliaries",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
}
]
},
{
"ProductID": "RTD000939",
"BrandName": "Hematoxylin II",
"ProductNameAddition": "",
"ReferenceType": "Reagent",
"Classification": [
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0027",
"StructureGroupPath": "Tissue->Research Reagents Ancillaries",
"StructureGroupName": "Research Reagents Ancillaries",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0017",
"StructureGroupPath": "Tissue->ISH Counterstains",
"StructureGroupName": "ISH Counterstains",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0007",
"StructureGroupPath": "Tissue->IHC Counterstains",
"StructureGroupName": "IHC Counterstains",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Grouping",
"NameofStructureSystem": "Product Grouping",
"StructureNodeID": "05-0006",
"StructureGroupPath": "Tissue->IHC Diluents",
"StructureGroupName": "IHC Diluents",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "20-000-00",
"StructureGroupPath": "Assays Reagents and Strips",
"StructureGroupName": "Assays Reagents and Strips",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
}
]
},
{
"ProductID": "INS_6476",
"BrandName": "BenchMark ULTRA PLUS",
"ProductNameAddition": "",
"ReferenceType": "Instrument",
"Classification": [
{
"IdentifierofStructureSystem": "1",
"NameofStructureSystem": "GPCH",
"StructureNodeID": "9570",
"StructureGroupPath": "Histology->Systems / Digital Products->Advanced Staining->BenchMark ULTRA PLUS",
"StructureGroupName": "BenchMark ULTRA PLUS",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Product_Types",
"NameofStructureSystem": "Product Types",
"StructureNodeID": "10-000-00",
"StructureGroupPath": "Analyzer Instruments and Systems",
"StructureGroupName": "Analyzer Instruments and Systems",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Family",
"NameofStructureSystem": "Product Families",
"StructureNodeID": "080",
"StructureGroupPath": "BenchMark",
"StructureGroupName": "BenchMark",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Lab_Type",
"NameofStructureSystem": "Lab Types",
"StructureNodeID": "080-00",
"StructureGroupPath": "Pathology Lab",
"StructureGroupName": "Pathology Lab",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Product_Solutions",
"NameofStructureSystem": "Product Solutions",
"StructureNodeID": "010",
"StructureGroupPath": "Histopathology",
"StructureGroupName": "Histopathology",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "075-00",
"StructureGroupPath": "In situ Hybridization (ISH)",
"StructureGroupName": "In situ Hybridization (ISH)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
"StructureNodeStatus": "Active"
},
{
"IdentifierofStructureSystem": "Applications",
"NameofStructureSystem": "Applications",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Disease_Areas",
"NameofStructureSystem": "Disease Areas",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
},
{
"IdentifierofStructureSystem": "Health_Topics",
"NameofStructureSystem": "Health Topics",
"StructureNodeID": "99-00-00",
"StructureGroupPath": "",
"StructureGroupName": "",
"StructureNodeStatus": "Inactive"
}
]
}
]
},
"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Intended Use",
"Value": "VENTANA anti-E-cadherin (36) Mouse Monoclonal Primary Antibody (VENTANA anti-E-cadherin (36)) est dirigé contre le domaine cytoplasmique de la protéine transmembranaire E-cadhérine humaine exprimée comme partie intégrante du complexe d’adhésion cellule-cellule dans les tissus épithéliaux. La diminution ou la perte d’expression de cette protéine est associée à un carcinome invasif et éventuellement à une métastase dans divers carcinomes. Cet anticorps peut être utilisé pour aider à faire la distinction entre un carcinome lobulaire in situ et/ou invasif et un carcinome canalaire in situ et/ou invasif du sein. Il est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine.
Les résultats des tests doivent être interprétés par un anatomopathologiste qualifié, en conjonction avec un examen histologique, les informations cliniques pertinentes et des contrôles appropriés.
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "E-cadherin is a 120 kDa cell adhesion glycoprotein that functions as a calcium-dependent regulator of tight cell-celladhesion in epithelial cells.1,2,3 In tumors, aberrations in E- cadherin result in the loss of cytoplasmic membrane localization of the protein and correlate with loss of adhesive properties and an increase in invasive and metastatic potential.3 Antibodies to E-cadherin have been used to characterize a variety of neoplasms, with breast applications being the most widely published.4,5,6
In breast, normal ductal cells show strong membranous E-cadherin expression. In tumors of ductal origin, the pattern of E-cadherin membrane staining persists. However, tumors of lobular origin frequently exhibit aberrant E-cadherin distribution, with a high frequency having cytoplasmic or no E-cadherin reactivity, which varies with the sample cohort being evaluated and the anti-E-cadherin clone utilized.4,5,6 While many lobular breast carcinomas do not stain with VENTANA anti-E-cadherin (36) Mouse Monoclonal Primary Antibody (VENTANA anti-E-cadherin (36) antibody), cytoplasmic staining can be observed along with weak, partial, and punctate membrane staining. Additionally, VENTANA anti-E- cadherin (36) antibody has been shown in the literature to demonstrate a nuclear staining pattern in several tumor types.7 Due to the unclear clinical significance of nuclear E- cadherin staining, the pathologist should note the presence of this staining pattern and exercise caution when interpreting VENTANA anti-E-cadherin (36) antibody-stained slides.
Detection of E-cadherin protein by immunohistochemistry (IHC) with the VENTANA anti-E- cadherin (36) antibody may be used to aid in the differentiation of lobular breast carcinoma from ductal breast carcinoma. It may be used as part of a panel of IHC studies.
1. Berx G, Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res. 2001;3(5):289-293.
2. Van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci. 2008;65(23):3756-3788.
3. Beavon, IR. The E-cadherin-catenin complex in tumour metastasis: structure, function, and regulation. European Journal of Cancer. 2000;36(13):1607-1620.
4. Acs G, et al. Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol. 2001;115(1):85-98.
5. Choi YJ, et al. Interobserver variability and aberrant E-cadherin immunostaining of lobular neoplasia and infiltrating lobular carcinoma. Mod Pathol. 2008;21(10):1224-1237.
6. Kowalski PJ, et al. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 2003;5(6):R217-R222.
7. Chetty R, Serra S. Nuclear E-cadherin immunoexpression: from biology to potential applications in diagnostic pathology. Adv Anat Pathol. 2008;15(4):234-240.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Content",
"Value": "VENTANA anti-E-cadherin (36) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of VENTANA anti-E-cadherin (36) antibody contains approximately 1.5 μg of a mouse monoclonal antibody.
The antibody is diluted in phosphate buffer with carrier protein and 0.10% ProClin 300, a preservative.
Specific antibody concentration is approximately 0.3 μ g/mL.
There is no known non-specific antibody reactivity observed in this product.
VENTANA anti-E-cadherin (36) antibody is a mouse monoclonal antibody produced from cell culture supernatant material.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and Limitations.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Principle",
"Value": "VENTANA anti-E-cadherin (36) antibody binds to the cytoplasmic domain of the human transmembrane protein E-cadherin in formalin-fixed paraffin-embedded (FFPE) tissue sections. This antibody can be visualized using ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001). Refer to the respective method sheet for further information.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "VENTANA anti-E-cadherin (36) Mouse Monoclonal Primary Antibody (VENTANA anti-E-cadherin (36)) est dirigé contre le domaine cytoplasmique de la protéine transmembranaire E-cadhérine humaine exprimée comme partie intégrante du complexe d’adhésion cellule-cellule dans les tissus épithéliaux. La diminution ou la perte d’expression de cette protéine est associée à un carcinome invasif et éventuellement à une métastase dans divers carcinomes. Cet anticorps peut être utilisé pour aider à faire la distinction entre un carcinome lobulaire in situ et/ou invasif et un carcinome canalaire in situ et/ou invasif du sein. Il est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine.
Les résultats des tests doivent être interprétés par un anatomopathologiste qualifié, en conjonction avec un examen histologique, les informations cliniques pertinentes et des contrôles appropriés.
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
