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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "CONFIRM anti-EMA (E29) contains sufficient reagent for 50 tests.

One 5 mL dispenser of CONFIRM anti-EMA (E29) antibody contains approximately 2.5 μg of a mouse monoclonal antibody.
The antibody is diluted in Tris HCl with carrier protein and 0.10% ProClin 300, a preservative.

Specific antibody concentration is approximately 0.5 μg/mL. There is no known non-specific antibody reactivity observed in this product.

CONFIRM anti-EMA (E29) antibody is produced as cell culture supernatant.

Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of theProcedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures,Troubleshooting, Interpretation of Results, and Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "CONFIRM anti-EMA (E29) Mouse Monoclonal Primary Antibody (CONFIRM anti-EMA (E29)) de Ventana Medical Systems (Ventana) est dirigé contre l’antigène épithélial membranaire exprimé sur la surface apicale des épithéliums glandulaires. Cette glycoprotéine est principalement localisée sur les membranes dans les tissus sains et tumoraux, bien qu’elle puisse présenter une localisation cytoplasmique dans les carcinomes moins différenciés. Cet anticorps peut être utilisé afin de faciliter l’identification de l’antigène épithélial membranaire dans les adénocarcinomes dérivés des épithéliums sécrétoires, dans les mésothéliomes malins, les carcinomes rénaux et les méningiomes. L’anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine.

Ce produit doit être interprété par un anatomopathologiste qualifié, en conjonction avec un examen histologique, les informations cliniques pertinentes et des contrôles appropriés.

Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "CONFIRM anti-EMA (E29) Mouse Monoclonal Primary Antibody (CONFIRM anti-EMA (E29)antibody) was raised against purified human milk fat globulin membrane preparation and specifically recognizes human epithelial membrane antigen (EMA).¹ EMA is a glycosylated transmembrane protein which lines the apical surface of epithelial cells in several organs and tissues including the lungs, stomach, pancreas, kidney, colon, and breast.^2-5

EMA expression is characteristic of most carcinomas but is generally absent in lymphomas, leukemias, melanomas, and sarcomas.^4-7There are some caveats; in particular, not all epithelial neoplasms are EMA positive: hepatocellular carcinomas, adrenocortical carcinomas, and malignant germ cell neoplasms exhibit little or no expression of EMA.⁸ An IHC assay to detect EMA is usefulas part of a panel of assays for the identification of carcinomas. The detection of EMA by IHC with CONFIRM anti-EMA (E29) antibody may be used to aid in the identification of tumors of epithelial origin.EMA expression can be detected in 69-95% of mesotheliomas and may aid in the diagnosis of these tumors.^9-12 EMA may be useful in distinguishing between reactive mesothelial hyperplasia (typically EMA negative) and mesothelioma (typically EMA positive).^9,11The detection of EMA by IHC with CONFIRM anti-EMA (E29) antibody may be used to aid in the diagnosis of mesothelioma.

Meningioma is one of the most common primary brain tumors and the majority of these lesions are slow growing and benign.¹³ EMA expression has been detected in 90-100% cases of meningioma.^14-17 IHC assays specific for EMA can be used to aid in the diagnosis these tumors.^14,18,19In the case of a differential diagnosis, the use of EMA in combination with other markers specific to meningioma as well as markers specific for the confounding tumor(s) should be used to confirm the diagnosis.^14,18,19The detection of EMA by IHC with CONFIRM anti-EMA (E29) antibody may be used toaid in the diagnosis of meningioma.

1. Heyderman E, Strudley I, Powell G, et al. A new monoclonal antibody to epithelial membrane antigen (EMA)-E29. A comparison of its immunocytochemical reactivity with polyclonal anti-EMA antibodies and with another monoclonal antibody. HMFG- 2. Br J Cancer. 1985;52:355-361.
2. Lau SK, Weiss LM, Chu PG. Differential Expression of MUC1, MUC2, and MUC5ac in Carcinomas of Various Sites: An Immunohistochemical Study. Am J Clin Pathol. 2004;122(1):61-69.
3. Lopez-Ferrer A, Curull V, Barranco C, et al. Mucins as Differentiation Markers in Bronchial Epithelium. Squamous Cell Carcinoma and Adenocarcinoma Display Similar Expression Patterns. Am J Respir Cell Mol Biol. 2001;24(1):22-29.
4. Pinkus GS, Kurtin PJ. Epithelial Membrane Antigen--a Diagnostic Discriminant in Surgical Pathology: Immunohistochemical Profile in Epithelial, Mesenchymal, and Hematopoietic Neoplasms Using Paraffin Sections and Monoclonal Antibodies. Hum Pathol. 1985;16(9):929-940.
5. Sloane JP, Ormerod MG. Distribution of Epithelial Membrane Antigen in Normal and Neoplastic Tissues and It Value in Diagnostic Tumor Pathology. Cancer. 1981;47(7):1786-1795.
6. Collado Martin R, Garcia Palomo A, de la Cruz Merino L, et al. Clinical Guideline SEOM: Cancer of Unknown Primary Site. Clin Transl Oncol. 2014;16(12):1091- 1097.
7. Massard C, Loriot Y, Fizazi K. Carcinomas of an Unknown Primary Origin-- Diagnosis and Treatment. Nat Rev Clin Oncol. 2011;8(12):701-710.
8. Wick MR. Immunohistochemical Approaches to the Diagnosis of Undifferentiated Malignant Tumors. Ann Diagn Pathol. 2008;12(1):72-84.
9. Arslan S BK, Elbeyli L. Epithelial Membrane Antigen in Differential Diagnosis of Malignant Mesothelioma, Metastatic Adenocarcinoma, and Reactive Mesothelial Hyperplasia. Turk Gogus Kalp Dama. 2016;24:108-112.
10. Lin W, Liu X, Cen Y.Diagnostic Accuracy of Epithelial Membrane Antigen for Malignant Effusions: A Meta-Analysis. Int J Biol Markers. 2016;31(1):e11-16.
11. Ordonez NG. The Immunohistochemical Diagnosis of Mesothelioma: A Comparative Study of Epithelioid Mesothelioma and Lung Adenocarcinoma. Am J Surg Pathol. 2003;27(8):1031-1051.
12. Saad RS, Cho P, Liu YL, et al. The Value of Epithelial Membrane Antigen Expression in Separating Benign Mesothelial Proliferation from Malignant Mesothelioma: A Comparative Study. Diagn Cytopathol. 2005;32(3):156-159.
13. Perry A, Gutmann DH, Reifenberger G. Molecular Pathogenesis of Meningiomas. J Neurooncol. 2004;70(2):183-202.
14. Boulagnon-Rombi C, Fleury C, Fichel C, et al. Immunohistochemical Approach to the Differential Diagnosis of Meningiomas and Their Mimics. J Neuropathol Exp Neurol. 2017;76(4):289-298.
15. Agaimy A, Buslei R, Coras R, et al. Comparative Study of Soft Tissue Perineurioma and Meningioma Using a Five-Marker Immunohistochemical Panel. Histopathology. 2014;65(1):60 -70.
16. Ghanghoria S, Sodhiya, P., Niranjan, V., Argal, V., & Ghanghoria, A. Diagnostic and Prognostic Evaluation of Meningioma by IHC Markers-a Study of 100 Cases. Journal of Medical Science and Clinical Research. 2019;07(02):382-390.
17. Takei H, Bhattacharjee MB, Rivera A, et al. New Immunohistochemical Markers in the Evaluation of Central Nervous System Tumors: A Review of 7 Selected Adult and Pediatric Brain Tumors. Arch Pathol Lab Med. 2007;131(2):234-241.
18. Commins DL, Atkinson RD, Burnett ME. Review of Meningioma Histopathology. NeurosurgFocus. 2007;23(4):E3.
19. Jaiswal S. Role of Immunohistochemistry in the Diagnosis of Central Nervous System Tumors. Neurol India. 2016;64(3):502-512.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Product Purpose", "Value": "CONFIRM anti-EMA (E29) Mouse Monoclonal Primary Antibody (CONFIRM anti-EMA (E29)) de Ventana Medical Systems (Ventana) est dirigé contre l’antigène épithélial membranaire exprimé sur la surface apicale des épithéliums glandulaires. Cette glycoprotéine est principalement localisée sur les membranes dans les tissus sains et tumoraux, bien qu’elle puisse présenter une localisation cytoplasmique dans les carcinomes moins différenciés. Cet anticorps peut être utilisé afin de faciliter l’identification de l’antigène épithélial membranaire dans les adénocarcinomes dérivés des épithéliums sécrétoires, dans les mésothéliomes malins, les carcinomes rénaux et les méningiomes. L’anticorps est destiné à la coloration qualitative de coupes de tissus fixés au formol et inclus en paraffine.

Ce produit doit être interprété par un anatomopathologiste qualifié, en conjonction avec un examen histologique, les informations cliniques pertinentes et des contrôles appropriés.

Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

CONFIRM anti-EMA (E29) Mouse Monoclonal Primary Antibody

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