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{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
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"Name": "Background Information",
"Value": "Anti-IgM reacts with immunoglobulin mu (IgM) chains. IgM is one of the predominant surface immunoglobulins on B-lymphocytes. This antibody is useful when differentiating and sub-classifying hematolymphoid neoplasms.
1-61. Arnold A, et al. Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. New Eng J Med. 1983; 309:1593-9.
2. Leong AS, et al. Manual of Diagnostic Antibodies for Immunohistology. Greenwich Medical Media Ltd. 1999. London. pp 217-9. Print.
3. Robinson JE, et al. Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus. New Eng J Med. 1980; 302:1293-7.
4. Taylor, CR. Immunoperoxidase techniques: practical and theoretical aspects. Arch Pathol Lab Med. 1978; 102:113-21.
5. Kojima M, et al. Primary marginal zone B-cell lymphoma of the lymph node resembling plasmacytoma arising from a plasma cell variant of Castleman’s disease. A clinicopathological and immunohistochemical study of seven patients. APMIS. 2002; 110:875-80.
6. Pambuccian SE, et al. Amyloidoma of bone, a plasma cell/plasmacytoid neoplasm. Report of three cases and review of the literature. Am J Surg Pathol. 1997; 21:179-86.",
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immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In
general, immunohistochemical staining allows the visualization of antigens via the sequential
application of a specific antibody (primary antibody) to the antigen, a secondary antibody
(link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate
with interposed washing steps. The enzymatic activation of the chromogen results in a visible
reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.
This antibody is optimally diluted to be compatible with VENTANA detection kits and
BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for
recommended staining protocols. Each step in the staining protocol includes incubation for
a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound
material that would hinder the desired reaction in subsequent steps. To minimize evaporation
of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied
in the slide stainer. For more detailed information on instrument operation, refer to the
appropriate BenchMark IHC/ISH instruments Operator’s Manual.",
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