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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "VENTANA ISH iVIEW Blue Detection Kit contains sufficient reagent for 200 tests.

One 20 mL dispenserVENTANA ISH iVIEW Blue Detection Kit contains approximately 0.5 µg/mL Anti-Fluorescein mouse monoclonal antibody in phosphate buffered saline with protein stabilizer and 0.10% ProClin 300, a preservative.
One 20 mL dispenserVENTANA ISH iVIEW Blue Detection Kit Biotinylated Ig contains approximately 10 µg/mL affinity-purified goat anti mouse IgG in phosphate buffered saline with protein stabilizer and 0.10% ProClin 300, a preservative.
One 20 mL dispenserVENTANA ISH iVIEW Blue Detection Kit Streptavidin Alkaline Phosphatase, approximately 1%, in Tris buffer with MgCl2 and ZnCl2 and 0.10% ProClin 300, a preservative.
One 20 mL dispenserVENTANA ISH iVIEW Blue Detection Kit Enhancer contains approximately 11% v/v MgCl2 solution with 0.10% ProClin 300, a preservative.
One 20 mL dispenserVENTANA ISH iVIEW Blue Detection Kit NBT contains nitro blue tetrazolium (0.5 g/L) in approximately 1% v/v dimethylformamide.
One 20 mL dispenserVENTANA ISH iVIEW Blue Detection Kit BCIP contains 5‑bromo‑4‑chloro‑3‑indolyl phosphate (0.5 g/L) in a Tris buffer.
", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le VENTANA ISH iVIEW Blue Detection Kit est un système de détection indirecte à la biotine et à la streptavidine des sondes marquées à la fluorescéine. Ce kit est conçu pour l’identification de cibles par hybridation in situ dans les coupes de tissus fixés au formol et inclus en paraffine qui sont colorées sur un appareil BenchMark IHC/ISH. Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Ce produit est conçu pour une utilisation en diagnostic in vitro (DIV).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "In general, in situ hybridization (ISH) uses labeled probes to detect specific DNA or RNA target sequences in fixed tissue specimens. Target sequences are exposed by heating the tissue and probe solution to denature nucleic acids. The reaction is then cooled allowing the labeled nucleic acid probe to hybridize to its complementary nucleic acid sequence in the tissue.

The hybridization of the probe to the nucleic acid sequence is visualized with an indirect detection method. A common indirect technique uses a biotinylated secondary antibody directed against the species of the primary anti-hapten antibody, and an enzyme linked with a corresponding substrate-chromogen system. This combination results in a colored precipitate at the site of specific antibody binding. The VENTANA ISH iVIEW Blue Detection Kit uses this indirect method to visualize complementary nucleic acid sequences by depositing a blue colored precipitate.


References

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  2. Occupational Safety and Health Standards: Occupational exposure to hazardous chemicals in laboratories. (29 CFR Part 1910.1450). Fed. Register.
  3. Directive 2000/54/EC of the European Parliament and Council of 18 September 2000 on the protection of workers from risks related to exposure to biological agents at work.
  4. Doria M, Lloyd D, Thistlethwaite JR, Franklin WA. Immunohistochemical detection of antibody in tissue sections of non‑perfused and ex vivo‑perfused organs using a tetrazolium alkaline phosphatase substrate. Histochemistry. 1988;89(5):443‑446.
  5. True LD. Atlas of Diagnostic Immunohistopathology. J.B. Lippincott Co., Philadelphia, PA, 1990.
  6. Roche PC, Hsi ED. Immunohistochemistry-Principles and Advances. Manual of Clinical Laboratory Immunology, 6th edition. In: NR Rose, ed. ASM Press; 2002.
  7. College of American Pathologists Laboratory Accreditation Program, Anatomic Pathology Checklist, 2001.
  8. CLSI (formerly NCCLS). Quality Assurance for Immunocytochemistry: Approved Guideline. CLSI document MM4-A- (ISBN 1-56238-396-5). CLSI, 940 West Valley Road, Suite 1400, Wayne, PA 19087-1898 USA, 1999.
  9. Taylor C, Cote RJ. Immunomicroscopy: A Diagnostic Tool for the Surgical Pathologist. 2nd Edition. Philadelphia, PA. W.B. Saunders Company; 1986.
", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "VENTANA ISH iVIEW Blue Detection Kit detects specific fluorescein-labeled probes bound to specific target sequences in formalin-fixed, paraffin-embedded (FFPE) tissue sections. VENTANA ISH iVIEW Blue Detection Kit contains mouse anti-fluorescein primary antibody that detects the fluorescein-labeled probes bound to the target sequence. The anti-fluorescein antibody is followed by the binding of a biotinylated secondary antibody consisting of goat anti mouse IgG. This step is followed by the addition of a Streptavidin-AP (alkaline phosphatase) enzyme conjugate which binds to the biotin present on the secondary antibody. The complex is then visualized with 5-Bromo-4- chloro-3-indolyl phosphate (BCIP) and nitro blue tetrazolium (NBT) chromogen, which produces a blue precipitate that is readily detected by light microscopy.

Unlike horseradish peroxidase, alkaline phosphatase is unaffected by endogenous peroxidase activity and is therefore more effective for labeling specimens heavily infiltrated with neutrophils or eosinophils. Nitro blue tetrazolium stains the tissue blue and has the advantages of a higher extinction coefficient, yielding a more intense color reaction at the site of probe target interaction.

The staining protocol consists of numerous steps in which reagents are incubated for predetermined times at specific temperatures. At the end of each incubation step, the BenchMark IHC/ISH instrument washes the sections to remove unbound material and applies a liquid coverslip which minimizes the evaporation of the aqueous reagents from the slide. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with positive staining for the probe.

For more detailed information on instrument operation, refer to the appropriate User Guide. Figure 1 illustrates the indirect detection method.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le VENTANA ISH iVIEW Blue Detection Kit est un système de détection indirecte à la biotine et à la streptavidine des sondes marquées à la fluorescéine. Ce kit est conçu pour l’identification de cibles par hybridation in situ dans les coupes de tissus fixés au formol et inclus en paraffine qui sont colorées sur un appareil BenchMark IHC/ISH. Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Ce produit est conçu pour une utilisation en diagnostic in vitro (DIV).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

VENTANA ISH iVIEWBlue Detection Kit

IVD For in vitro diagnostic use.
VENTANA ISH <i>i</i>VIEW<sub>Blue</sub> Detection Kit

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