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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "Myogenin also identified as myogenic factor 4 is a muscle specific transcription factor associated with muscle differentiation and cell cycle.1 Anti-myogenin reactivity is seen in the nuclei of myoblasts in developing muscle tissue. Anti-myogenin is a useful immunohistochemical reagent for identification of rhabdomyosarcoma.2-5

1. Miller JB. Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin. J Cell Biol. 1990; 111:1149-59.
2. Wang NP, et al. Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood. Am J Pathol. 1995; 147:1799-810.
3. Cui S, et al. Evaluation of new monoclonal anti-MyoD1 and anti-myogenin antibodies for the diagnosis of rhabdomyosarcoma. Pathol Int. 1999; 49:62-8.
4. Kaspar et al. The expression of c-Myb correlates with the levels of rhabdomyosarcomaspecific marker myogenin. Sci Rep. 2015; 5:15090.
5. Rudzinski et al. Myogenin, AP 2 Beta, NOS-1 and HMGA2 are surrogate markers of fusion status in rhabdomyosarcoma. Am J Surg Pathol. 2014; 38:654-9.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le Myogenin (F5D) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine myogénine dans les tissus humains fixés au formol et enrobés à la paraffine, colorés par immunohistochimie (IHC) qualitative sur les instruments BenchMark IHC/ISH.

Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés.

Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Principle", "Value": "Myogenin (F5D) Mouse Monoclonal Antibody (this antibody) may be used as the primary
antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue
sections. In general, immunohistochemical staining allows the visualization of antigens
via the sequential application of a specific antibody (primary antibody) to the antigen, a
secondary antibody (link antibody) to the primary antibody, an enzyme complex and a
chromogenic substrate with interposed washing steps. The enzymatic activation of the
chromogen results in a visible reaction product at the antigen site. The specimen may then be
counterstained and a coverslip applied. Results are interpreted using a light microscope and
aid in the differential diagnosis of pathophysiological processes, which may or may not be
associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le Myogenin (F5D) Mouse Monoclonal Primary Antibody est destiné à un usage en laboratoire pour détecter la protéine myogénine dans les tissus humains fixés au formol et enrobés à la paraffine, colorés par immunohistochimie (IHC) qualitative sur les instruments BenchMark IHC/ISH.

Ce produit doit être interprété par un pathologiste compétent en parallèle avec un examen histologique, les informations cliniques pertinentes et les contrôles appropriés.

Cet anticorps est destiné à être utilisé aux fins de diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

Myogenin (F5D) Mouse Monoclonal Antibody

IVD For in vitro diagnostic use.
Myogenin (F5D) Mouse Monoclonal Antibody

Description

Detailed Specifications

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