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"Value": "Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of the tumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheral nervous system.
1,2 In normal tissue, NGFR is expressed in neural crest derived cells, lymphoid follicular dendritic cells seen in lymph nodes and tonsils, and myoepithelial cells of the breast, prostate, and salivary gland as well as basal epithelium of the respiratory system.
1,2 NGFR has been shown to be a reliable adjunct marker for melanoma, specifically desmoplastic and spindle cell variants.
3-4 Anti-NGFR labels myoepithelial cells of the breast and may aid in the differentiation between benign conditions, pre-invasive neoplastic lesions and invasive malignacies of the breast.
1. Thompson SJ. A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue. Am J Clin Pathol. 1989; 92:415-23.
2. Reis-Filho JS, et al. Distribution and significance of nerve growth factor receptor (NGFR/ p75NTR) in normal, benign and malignant breast tissue. Mod Pathol. 2006; 19:307-19.
3. Lazova R, et al. P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. J Am Acad Dermatol. 2010; 63:852-8.
4. Kanik AB, et al. p75 nerve growth factor receptor staining helps identify desmoplastic and neurotropic melanoma. J Cutan Pathol. 1996; 23:205-10.",
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