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"IdentifierofStructureSystem": "OWP_Techniques",
"NameofStructureSystem": "Techniques",
"StructureNodeID": "073-00",
"StructureGroupPath": "Immunohistochemistry (IHC)",
"StructureGroupName": "Immunohistochemistry (IHC)",
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"IdentifierofStructureSystem": "Pathogens",
"NameofStructureSystem": "Pathogens",
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"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Name": "Storage Conditions (Product)",
"Value": "Upon receipt and when not in use, store at 2-8°C. Do not freeze.",
"Language": "en",
"Country": "XG",
"Code": "Storage Conditions (Product)"
},
{
"Name": "Content",
"Value": "Anti-p40 (BC28) antibody contains sufficient reagent for 50 tests.
One 5 mL dispenser of anti-p40 (BC28) antibody contains approximately 2.0 μg of a mouse monoclonal antibody.
The antibody is diluted in Tris-HCl with carrier protein and 0.10% ProClin 300, a preservative. Specific antibody concentration is approximately 0.4 μg/mL. There is no known non- specific antibody reactivity observed in this product.",
"Language": "en",
"Country": "XG",
"Code": "Content"
},
{
"Name": "Intended Use",
"Value": "Anti-p40 (BC28) Mouse Monoclonal Primary Antibody est conçu pour une utilisation en laboratoire dans la détection immunohistochimique qualitative de la protéine p40 par microscopie optique dans des tissus fixés au formol et inclus en paraffine (FFPE) colorés sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un pathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Intended Use"
},
{
"Name": "Background Information",
"Value": "Anti-p40 (BC28) Mouse Monoclonal Primary Antibody (anti-p40 (BC28) antibody) is a mouse monoclonal antibody raised for the detection of the p40 isoform of the p63 protein. The p63 protein is a member of the p53 family of transcription factors.1 Five isoforms of p63 (α, β, γ, δ, ε) can be produced due to alternative splicing and an additional 5 isoforms lacking the N-terminal transactivation domain (ΔNp63/p40 α, β, γ, δ, ε) can be produced due to the presence of a second promoter site within the gene.1,2
p40 is expressed in the basal or progenitor cells of epithelial tissues and glandular structures including the prostate and bronchi.3,4 In the prostate, p40 is expressed in the basal cells of almost all normal and benign glands but is not present in the neuroendocrine or luminal secretory cells.4,5 The presence of basal cells, as marked by the presence of p40 staining, is a feature of normal and benign prostatic processes.5 The absence of basal cells is a hallmark of prostatic malignancies.6 The immunohistochemical (IHC)- based detection of p40 in prostatic basal cells, using anti-p40 (BC28) antibody can be used to aid in the differentiation of benign and malignant prostate lesions.
In lung, p40 is expressed in the basal cell compartment.3 It has been speculated that squamous cell carcinoma (SCCA) of the lung originates from the basal compartment.7 Malignant squamous differentiation is characteristic of the SCCA subtype of non-small cell lung cancer (NSCLC).8 Thus, the overexpression of p40 in NSCLC can be an indicator of malignant squamous differentiation.8,9,10 The adenocarcinoma (ADC) subtype of NSCLC typically does not exhibit p40 expression like SCCA.8 Thus, detection of p40 using anti- p40 (BC28) antibody may be used as a marker of squamous differentiation to aid in the distinction between pulmonary SCCA and ADC.
In contrast to the anti-p63 antibody (clone 4A4) that recognizes p63 and p40 variants, the anti-p40 (BC28) antibody recognizes only the p40 isoform.9 Studies indicate that anti-p40 (BC28) antibody is more specific for SCCA than anti-p63 (4A4) antibody.9,10 Thus, it is recommended to use anti-p40 (BC28) antibody to aid in the distinction between pulmonary SCCA and ADC.11
This antibody may be used as part of a panel of IHC studies.
1. Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998;2(3):305-316.
2. Mangiulli M, Valletti A, Caratozzolo MF, et al. Identification and Functional Characterization of Two New Transcriptional Variants of the Human P63 Gene. Nucleic Acids Res. 2009;37(18):6092-6104.
3. Nobre AR, Albergaria A, Schmitt F. p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta Cytol. 2013;57(1):1-8.
4. Signoretti S, Waltregny D, Dilks J, et al. P63 Is a Prostate Basal Cell Marker and Is Required for Prostate Development. Am J Pathol. 2000;157(6):1769-1775.
5. Sailer V, Stephan C, Wernert N, et al. Comparison of P40 (Deltanp63) and P63 Expression in Prostate Tissues--Which One Is the Superior Diagnostic Marker for Basal Cells? Histopathology. 2013;63(1):50-56.
6. Epstein JI, Egevad L, Humphrey PA, et al. Best Practices Recommendations in the Application of Immunohistochemistry in the Prostate: Report from the International Society of Urologic Pathology Consensus Conference. Am J Surg Pathol. 2014;38(8):e6-e19.
7. Hanna JM, Onaitis MW. Cell of Origin of Lung Cancer. J Carcinog. 2013;12:6.
8. Travis WD, Brambilla E, Nicholson AG, et al. The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances since the 2004 Classification. J Thorac Oncol. 2015;10(9):1243-1260.
9. Tacha D, Bremer R, Haas T, et al. An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers. Arch Pathol Lab Med. 2014;138(10):1358-64.
10. Bishop JA, Teruya-Feldstein J, Westra WH, et al. p40 (DeltaNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 2012;25(3):405-415.
11. Yatabe Y, Dacic S, Borczuk AC, et al. Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer. J Thorac Oncol. 2019;14(3):377- 407.",
"Language": "en",
"Country": "XG",
"Code": "Background Information"
},
{
"Name": "Principle",
"Value": "Anti-p40 (BC28) antibody is a mouse monoclonal antibody produced against a synthetic peptide representing the p40 amino acid sequence from amino acid 5 to 17. Anti-p40 (BC28) antibody binds to p40 protein in formalin-fixed, paraffin-embedded (FFPE) tissue sections and exhibits a nuclear staining pattern. This antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001) or ultraView Universal DAB Detection Kit (Cat. No. 760-500 / 05269806001) in combination with Amplification Kit (Cat. No. 760-080 / 05266114001). Refer to the respective method sheet for further information.
In addition to staining with the anti-p40 (BC28) antibody, a second slide should be stained with the appropriate negative control reagent.",
"Language": "en",
"Country": "XG",
"Code": "Principle"
},
{
"Name": "Product Purpose",
"Value": "Anti-p40 (BC28) Mouse Monoclonal Primary Antibody est conçu pour une utilisation en laboratoire dans la détection immunohistochimique qualitative de la protéine p40 par microscopie optique dans des tissus fixés au formol et inclus en paraffine (FFPE) colorés sur un appareil BenchMark IHC/ISH.
Ce produit doit être interprété par un pathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.
Cet anticorps est conçu pour une utilisation en diagnostic in vitro (DIV).",
"Language": "fr",
"Country": "XG",
"Code": "Product Purpose"
}
]
}
}
]
}
