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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "VENTANA pan-TRK (EPR17341) Assay contains sufficient reagent for 50 tests.

One 5 mL dispenser of VENTANA pan-TRK (EPR17341) Assay contains approximately 140 μg of a rabbit monoclonal antibody.

The antibody is diluted in 0.05 M Tris buffered saline, 0.01 M EDTA, 0.05% Brij-35 with 0.3% carrier protein and 0.05% sodium azide, a preservative.
Total protein concentration of the reagent is approximately 10 mg/mL.
Specific antibody concentration is approximately 28 μg/mL. There is no known non-specific antibody reactivity observed in this product.
VENTANA pan-TRK (EPR17341) Assay is produced as a Protein A purified recombinant rabbit monoclonal antibody.

Refer to the OptiView DAB IHC Detection Kit package insert for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Results, and General Limitations.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "Le VENTANA pan-TRK (EPR17341) Assay est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique des récepteurs TRK (tropomyosin receptor kinase) A, B et C dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour être utilisé dans le cadre du diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "VENTANA pan-TRK (EPR17341) Assay is a rabbit monoclonal primary antibody directed against the C-terminal region of TRK A, B and C proteins, also known as pan-TRK. The TRK family is composed of three transmembrane protein receptors (TRKA, TRKB, TRKC) that are encoded by the neurotrophic receptor tyrosine kinase (NTRK) genes (NTRK1, NTRK2, NTRK3), respectively.1-5 The sequence of these TRK family members are highly conserved but they are activated by different neurotrophins.1,2,3 In normal physiology, TRK receptors are preferentially expressed in tissues of neural origin and help regulate cell differentiation and survival; they also play a physiological role in the development of the central and peripheral nervous systems.1-4
NTRK gene alterations, including point mutations, splice variants, amplification, and fusions, are detected in various tumor types.1-5 Chimeric fusions involving NTRK1, NTRK2, or NTRK3 are the most common of these NTRK alterations.1-5 There are over 80 NTRK fusions reported and chimeric partners include ETV6, EML4, LMNA, and TPM3.1,2,3 The results of these fusion events are oncogenes that are aberrantly expressed.1-5 Preservation of the TRK kinase domain in these NTRK fusions drive carcinogenesis through constitutive activation of pathways that regulate cell survival, proliferation, invasion, and angiogenesis.1-5
Wild-type TRK protein expression in most solid tumors is generally minimal and of low prevalence.4,5 However, wild-type TRK protein expression can be substantial in some neuroendocrine tumor tissues.4,5 Conversely, detection of chimeric NTRK fusion cases is rare and their variable prevalence across numerous tumor types (< 0.5-1.0% of cancers overall) has made it challenging to detect TRK fusion proteins.4-8 Thus, due to the nondiscriminatory nature of pan-TRK IHC in the detection of wild-type and chimeric TRK proteins, tumors displaying any positivity should be further characterized by a molecular and/or cytogenetic method to determine NTRK status.5,7,8
Staining with the VENTANA pan-TRK (EPR17341) Assay was observed in multiple localizations (nuclear, cytoplasmic and membranous).

1. Khotskaya YB, Holla VR, Farago AF, et al. Targeting TRK Family Proteins in Cancer. Pharmacol Ther. 2017;173:58-66.
2. Cocco E, Scaltriti M, Drilon A. NTRK Fusion-Positive Cancers and TRK Inhibitor Therapy. Nat Rev Clin Oncol. 2018;15(12):731-747.
3. Amatu A, Sartore-Bianchi A, Bencardino K, et al. Tropomyosin Receptor Kinase (TRK) Biology and the Role of NTRK Gene Fusions in Cancer. Annals of Oncology. 2019;30:VIII5-VIII15.
4. Wong D, Yip S, Sorensen PH. Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer. Pathol Oncol Res. 2020;26(3):1385-1399.
5. Solomon JP, Benayed R, Hechtman JF, et al. Identifying Patients with NTRK Fusion Cancer. Annals of Oncology. 2019;30:VIII16-VIII22.
6. Kummar S, Lassen UN. TRK Inhibition: A New Tumor-Agnostic Treatment Strategy. Target Oncol. 2018;13(5):545-556.
7. Hsiao SJ, Zehir A, Sireci AN, et al. Detection of Tumor NTRK Gene Fusions to Identify Patients Who May Benefit from Tyrosine Kinase (TRK) Inhibitor Therapy. J Mol Diagn. 2019;21(4):553-571.
8. Marchio C, Scaltriti M, Ladanyi M, et al. ESMO Recommendations on the Standard Methods to Detect NTRK Fusions in Daily Practice and Clinical Research. Ann Oncol. 2019;30(9):1417-1427.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "VENTANA pan-TRK (EPR17341) Assay binds to the TRK epitope in n formalin-fixed, paraffin-embedded (FFPE) tissue sections. The specific antibody can be visualized using OptiView DAB IHC Detection Kit (Cat. No. 760-700 / 06396500001). Refer to the OptiView DAB IHC Detection Kit method sheet for further information.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "Le VENTANA pan-TRK (EPR17341) Assay est destiné à être utilisé en laboratoire pour la détection immunohistochimique qualitative par microscopie optique des récepteurs TRK (tropomyosin receptor kinase) A, B et C dans des coupes de tissus fixés au formol et inclus en paraffine colorées sur un appareil BenchMark IHC/ISH.

Ce produit doit être interprété par un anatomopathologiste qualifié, en complément d’examens histologiques, d’informations cliniques pertinentes et de contrôles adaptés.

Cet anticorps est conçu pour être utilisé dans le cadre du diagnostic in vitro (IVD).", "Language": "fr", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

VENTANA pan-TRK (EPR17341) Assay

IVD For in vitro diagnostic use.
VENTANA pan-TRK (EPR17341) Assay

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