The SCC assay is used as an aid in the management of patients with squamous cell carcinoma in conjunction with other methods that align to the standard clinical management guidelines.
SCCA levels can be elevated in squamous cell cancers and it has been reported that more advanced cancer stages are associated with higher SCCA levels especially in lung and cervical cancer.1,2 It was reported that measurement of the antigen, in serial determinations, aids in the assessment of disease recurrence, residual disease following treatment, and response to therapy.3,4
SCC antigen in different types of squamous cell cancers:
- SCCA has been reported as a biomarker for a non-small cell lung cancer (NSCLC), mainly of the squamous cell carcinoma type. SCC in lung is closely correlated with a history of tobacco smoking, more than other types of lung cancer.5 Based on literature, SCCA elevated serum levels were found to be indicative of NSCLC if renal failure and dermatological diseases were excluded.6
- The most common histology in cervical cancer is SCC, with SCCA being the biomarker of choice for this histology. Serum levels of SCCA have been found to correlate with tumor stage, tumor size and residual tumor after treatment, recurrent or progressive disease, and survival in patients with squamous cell cervical cancer.7,8
Benefits
- Measuring SCC antigen in lung cancer patients gives a clearer picture on the patients status
- SCC antigen as biomarker for cervical cancer is another tool in patient management together with other markers for gynecological malignancies (i.e. CA 125, HE4, CA 15-3, HPV, CINtec® PLUS Cytology)
- High assay precision for accurate and sustainable results for patient monitoring
- One blood sample for all lung cancer biomarkers for time and cost efficiency
- High reagent on-board stability
- Short turn around time for fast results