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Elecsys® AMH (Anti-Mullerian Hormone)

Providing clinical confidence in reliable ­assessment of ovarian reserve and prediction of response to controlled ovarian stimulation

Elecsys® AMH (Anti-Mullerian Hormone)

Providing clinical confidence in reliable assessment of ovarian reserve and prediction of response to controlled ovarian stimulation

Mean female age at first birth has increased steadily over the past few decades in many developed countries. This postponement leads to couples attempting to have children during a period where female fertility is already in decline.

 

Anti-Müllerian hormone (AMH)

 

AMH is a direct serum marker of functional ovarian reserve and plays an important role in assessing ovarian reserve levels and therefore the capacity to provide eggs for fertilization.1,2

Serum AMH levels have been shown to remain relatively stable during the menstrual cycle and may be measured on any day of the cycle.1,2

AMH is a reliable marker for prediction of response to controlled ovarian stimulation and can therefore add prognostic information to the counseling and planning process for infertile couples seeking treatment.3

 

  • Fully automated, fast, sensitive and robust measurement of AMH4
  • High precision over entire measuring range for reliable results4,5
  • Clinical agreement with Antral-Follicle-Count (AFC)6
  • Age specific reference ranges and PCOS (polycystic ovary syndrome) expected values5
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Elecsys® AMH (Anti-Mullerian Hormone)

Elecsys® AMH (Anti-Mullerian Hormone)

  • Assay time

    18 min

  • Sample material

    Serum and Li-heparin plasma

  • Sample volume

    50 µL

  • Detection Limit

    0.010 ng/mL, (0.071 pmol/L)

  • Measuring range

    0.01 - 23 ng/mL (0.071 - 164.2 pmol/L)

  • Imprecision

    <5%

  • LoB, LoD, LoQ

    0.049 pmol/L (0.007 ng/mL), 0.07 pmol/L (0.010 ng/mL), 0.21 pmol/L (0.030 ng/mL)

  • Repeatability

    1 - 2.6 % CV (0.33 - 91.1 pmol/L: 0.046 - 20.8 ng/mL)

  • Intermediate Precision

    2.5 - 3.9 % CV (0.33 - 91.1 pmol/L: 0.046 - 20.8 ng/mL)

References

  1. Van Disseldorp, J. et al. (2010). Hum Reprod; 25:221–227.
  2. Tsepelidis, S. et al. (2007). Hum Reprod; 22:1837–1840.
  3. The Practice Committee of the American Society for Reproductive Medicine. (2011). Fertil Steril; 98:1407–1415.
  4. Anti-Müllerian Hormone. Elecsys and cobas e analyzers package insert 2020.
  5. Anckaert E, Öktem M, et al. (2016). Clin Biochem 49(3):260-7
  6. Anderson, R.A., Anckaert, E., Bosch, E. et al. (2015). Fertil Steril; 103(4):1074–1080.e4.