Search
User Profile
Change
Select your user profile

Elecsys® Calcitonin

A powerful tool to aid in the diagnosis and monitoring of medullary thyroid carcinoma (MTC)

Elecsys® Calcitonin

A powerful tool to aid in the diagnosis and monitoring of medullary thyroid carcinoma (MTC)

Thyroid carcinoma is the most common malignancy of the endocrine system. In 5 to 10% of all thyroid carcinoma patients, a medullary thyroid carcinoma (MTC) is identified.1 These carcinomas produce elevated serum concentrations of calcitonin and, therefore, can be diagnosed with an exceptional degree of accuracy and specificity using immunoassays measuring serum calcitonin.2,3

The diagnostic marker calcitonin is a sen­sitive and specific tumor marker aiding in the ­diagnosis, as well as for the life-long monitoring of MTC patients after thyroid surgery.2,3

 

A marker with high specificity for MTC (Figure 1)

 

  • Sensitive tool for diagnosis and follow-up of MTC
  • High correlation with tumor burden, ­supporting early detection of new or ­residual disease2

 

Elecsys® Calcitonin with high precision

 

  • High precision across the entire ­measuring range support accurate results4

 

Workflow efficiency with the most complete automated thyroid portfolio

 

  • All tests required for differential diagnosis of thyroid diseases are consolidated on one platform, including routine thyroid ­assays and specialties such as Elecsys TgII, Elecsys Calcitonin, Elecsys Anti-Tg, Elecsys Anti-TPO and Elecsys Anti-TSHR.
Elecsys Calcitonin

Figure 1: Calcitonin is a highly specific marker for MTC, allowing early and specific diagnosis and reliable monitoring. Source: Performance Evaluation Study 2013, data available upon request.

Contact Us

Elecsys® Calcitonin

  • Assay time

    18 min.

  • Sample material

    Serum, Li-heparin ­plasma, K2-EDTA plasma, K3-EDTA plasma

  • Sample volume

    30 / 50 μL (depending on analyzer used)

  • LoB, LoD, LoQ*

    0.3 pg/mL, 0.5 pg/mL, 1 pg/mL

  • Measuring range

    0.5 – 2,000 pg/mL

  • Traceability

    IRP WHO 89/620

  • Total imprecision

    cobas e 411: 4.6 - 11.8%
    cobas e 601/2: 2.3 - 6.1%
    cobas e 402, cobas e 801: 2.5 - 4.7%

     

* LoB = Limit of Blank; LoD = Limit of Detection; LoQ = Limit of Quantitation with a total allowable error of ≤20 %

References

 

  1. Fedala et al. (2016). The interest of Calcitonin in the Diagnosis and the treatment of Medullary Thyroid Cancer, Journal of Dental and Medical Sciences, 15(12):109-111
  2. Bories, P.N., et al. (2016). Comparison of the Elecsys calcitonin assay with the Immulite 1000 assay. Describing one case with heterophilic antibody interference. Clin Chem Lab Med, 54:e45–7.
  3. Wells et al. 2015, Revised American Thyroid Association Guidelines for the Management of Medullar Thyroid Carcinoma. Thyroid 25(6): 567-616
  4. Elecsys® Anti-hCT (Mat. No. 09005668190) method sheet, V1 2022-02 & Elecsys® hCT (Mat. No. 09005676190) method sheet, V1 2022-03.