HPV mRNA Probes

• HPV E6 and E7 are biologically relevant markers.
• Raw material for laboratory developed tests (LDTs)/Analyte Specific Reagent.*
  
• The HPV mRNA probes are DNP hapten labeled probes designed to bind to their respective HPV E6/E7 mRNA transcripts.
• Five HPV mRNA probes are available:  HPV 6, HPV 11, HPV 16, HPV 18 and HPV 33.

Figure 1. Two of the early HPV genes encode for the oncoproteins E6 and E7. mRNA transcription in cells indicates active viral processes. Overexpression of E6 and E7 mRNA precedes transformation of cells. In persistent high risk HPV infections, E6 and E7 oncoproteins disrupt the p53 and retinoblastoma protein (pRb) cell cycle control mechanisms respectively.