At proCardio2022, Dr. Rick Pleijhuis (University Medical Center Groningen, The Netherlands) shared his insights into the use of digital decision support tools and disease management solutions in cardiovascular care. Digital decision support tools aim to improve informed clinical decision-making and ultimately provide the opportunity for personalised healthcare. A variety of digital decision support tools, e.g., algorithms, have been developed for cardiovascular care, including web-based and mobile device applications. However, from a regulatory perspective, there are several barriers to the implementation of these tools in clinical practice. Dr. Pleijhuis explains that the current landscape of digital decision support tools is fragmented and lacks standardisation. There is an absence of external validation, and it is difficult to integrate these applications into hospital infrastructures and electronic medical record systems. Dr. Pleijhuis believes a standardised approach using a centralised digital platform capable of hosting all types of digital decision support tools and external validation of applications is therefore needed. The lack of external validation and quality control may also lead to wariness among physicians regarding which digital decision support tools to trust, which can reduce their implementation. As a way forward, Dr. Pleijhuis recommends to externally validate existing digital decision support tools before developing new ones. Additionally, when developing new applications, it is important to consider system integration, its intended use and to have a plan in place for its external validation.