Cardiovascular disease (CVD) encompasses a range of conditions, including coronary artery disease, heart failure, arrhythmias, and stroke. According to the World Health Organization (WHO), CVD accounts for approximately 17.9 million deaths annually, representing 31% of all global deaths.1 The broad presentation of CVD often requires immediate and precise intervention to improve patient outcomes. About 20% of emergency room visits are preventable, with half being for cardiovascular conditions.2 The complexity of diagnosing and managing CVD, particularly in the emergency room, necessitates advanced digital triage tools to support clinical decision making and reduce emergency room visits.
The role of clinical decision support tools (CDSTs)
Clinical decision support tools (CDSTs) are computer-based systems designed to assist healthcare professionals during emergency room triage and follow-up. They integrate patient data, clinical guidelines, and predictive algorithms to provide tailored and specific treatment recommendations. These tools can enhance diagnostic accuracy, streamline workflows, support timely interventions, and improve adherence to guidelines, ultimately leading to better patient outcomes.3,4 However, challenges to their implementation include poor familiarisation of physicians with technology, integration difficulties with electronic health records, and bandwidth issues within the digital health infrastructure.
One of the primary applications of CDSTs in CVD management is during chest pain triage to enhance diagnostic accuracy. For example, CDSTs can analyse high-sensitivity troponin (hs-troponin) levels along with other clinical parameters to stratify a patient’s risk of CVD and guide further testing or treatment.5,6
The current triage of chest pain patients is done using an algorithm that is part of the ESC [European Society of Cardiology] recommendations, so patients have to have a pretest probability for the disease or for acute coronary syndrome
Dr. Giannitsis
The implementation of electronic health records integrated with CDSTs can also improve the efficiency of patient care by reducing the time spent on documentation.7
Expert opinions on CDSTs
Professor Christopher Baugh and Professor Evangelos Giannitsis highlight the significant role of digital decision support tools in the emergency room. They discuss that crowding, staffing shortages, and high patient throughput are the biggest challenges in the emergency room. CDSTs can aid in the accurate classification and triage of patients, potentially addressing these challenges.
Real-world examples and benefits
Several digital technologies have been developed for the management of CVD within the emergency room. Notable examples include the HEART score and the Global Registry of Acute Coronary Events (GRACE) score, both of which aid in risk stratification and have been shown to improve the efficiency of care.8-11
The HEART score is a widely used interactive tool for risk stratification in patients with chest pain. It incorporates five elements: patient history, ECG, age, risk factors and troponin levels and categorises patients into low, intermediate, and high-risk groups, guiding further diagnostic and therapeutic decisions.8 Studies show that its use can reduce unnecessary admissions and improve the efficiency of care in the emergency room.9
The GRACE score is used to predict the risk of death and AMI in patients with acute coronary syndrome (ACS) by integrating clinical variables such as age, heart rate, systolic blood pressure, and creatinine levels.10 The use of the GRACE score in the emergency room has been associated with an improved risk prediction of mortality in patients with ACS and can help identify high risk patients who may benefit from more aggressive treatment and close monitoring.10,11
Electronic solutions can overcome some limitations, for example, improve guideline adherence and improve quality of care for patients. They even can reduce the length of hospital stay and therefore increase patient satisfaction and reduce costs for staff, patient treatment and monitoring.
Dr. Baugh
Recent advancements in artificial intelligence (AI) have also led to machine learning algorithms that provide high accuracy in predicting patient outcomes and guiding treatment plans. Machine learning algorithms can also be used to predict the risk of adverse events, such as heart failure exacerbations, allowing for early intervention and improved patient outcomes.12 A recent study demonstrated serial ECGs from an individual had greater ability to predict new‐onset atrial fibrillation than an AI machine learning model based on a single ECG.13
Clinical decision support tools offer numerous benefits, including improved diagnostic accuracy, enhanced patient outcomes, and reduced healthcare costs. By integrating multiple data sources and applying evidence-based algorithms quickly, CDSTs reduce the likelihood of diagnostic errors and ensure that patients receive appropriate care promptly.3 Studies demonstrate that CDSTs in managing acute coronary syndrome (ACS) can reduce mortality and morbidity rates and support personalised care by tailoring recommendations to individual patient characteristics.12,14
Challenges and limitations
While CDSTs provide broad benefits, challenges remain, including data quality and completeness, user acceptance, and ethical and legal considerations. Accurate data input and seamless integration with existing electronic health record systems are crucial for successful implementation. Overcoming resistance to change and ensuring healthcare professionals are adequately trained are essential for the adoption of CDSTs. Professor Giannitsis suggests there is poor familiarisation with digital devices in a very heterogeneous healthcare landscape. Additionally, addressing bandwidth issues within the digital health infrastructure is necessary for the widespread use of these tools.
Future prospects
"There is a lot of excitement over what AI could bring to complement the clinician, to make him or her more efficient and safer in their practice of emergency medicine and to take them away from the computer and to the bedside where they want to be spending their time,” said Dr. Baugh. Advancements in technology and data science offer new opportunities for their use in emergency rooms and broader clinical practice. The integration of CDSTs with wearable devices and remote monitoring systems can provide continuous data on patients' cardiovascular health, enabling early detection and proactive management.15 Furthermore, the use of CDSTs in clinical research can enhance patient recruitment, retention, and the development of new clinical guidelines.
Conclusion
CDSTs have the potential to revolutionise the management of CVD in the emergency room by improving diagnostic accuracy, streamlining workflows, and supporting timely interventions. Addressing challenges related to data quality, user acceptance, and ethical considerations is essential for their successful implementation. Ongoing advancements in technology hold promise for further enhancing personalised medicine and clinical research. By embracing CDSTs and integrating them into routine emergency room practices, healthcare professionals can significantly improve patient outcomes and quality of life for those with CVD.
We have to improve healthcare delivery for the sake of the patient and every effort that we make is beneficial for them. I believe that implementation of clinical decision tools using algorithms that are based on knowledge and on guidelines will be very helpful in the future.
Dr. Giannitsis