For localized information and support, would you like to switch to your country-specific website for {0}?
cobas® b 221 <2> system
IVD
For in vitro diagnostic use.
More than a blood gas analyzer
The cobas® b 221 system is a fully automated analyzer for blood gas testing, offering a comprehensive configurable menu on various sample types.1 It can be used with whole blood, serum, plasma, dialysis solutions containing acetate or bicarbonate, and pleural fluid for blood gases (pH, pCO2, and pO2), electrolytes, hematocrit, metabolites, total hemoglobin, oxygen saturation, hemoglobin derivatives, and bilirubin (neonatal).
The cobas b 221 system is designed for mid to high sample throughputs, delivering reliable results in under two minutes. It supports efficient and convenient blood gas diagnosis in hospital laboratories and point-of-care settings, including intensive care units (ICU, NICU, PICU*), emergency departments (A&E, ER), and operating rooms (OR).
Use left and right arrow keys to scroll between the tabs
Overview
Product specifications
View full tableProduct specifications
| Product specification | Value |
| Parameters | 18 measured parameters and 35 calculated parameters
Blood gas: PCO2, PO2, pH Electrolytes + Hct (ISE): Na+, K+, Cl, Ca2+, Hct Metabolites (MSS): Glu, Lac, Urea CO-oximetry (COOX): tHb, O2Hb, HHb, CoHb, MetHb, SO2, Bili |
| Sample throughput | 31 samples/hour (BG)(MSS)(ISE)(COOX) |
| Sample types |
|
| Sample volume | 88 – 221 mL (depending on parameter configuration, Hct concentration and sample mode) |
| Measurement principles |
|
| Dimensions | 32 cm x 47 cm x 37 cm (W x H x D) |
| Weight | Approximately 46.2 kg (without wash/calibrating solutions and AutoQC) 24.5 kg (with Fluid Pack and AutoQC Pack) |
cobas b 221 system versions²
View full tablecobas b 221 system versions²
| Versions 2 |
4 |
6 |
|
|---|---|---|---|
| Blood gases (pH, pO2, pCO2, pH) / Co-oximetry | x | x | x |
| Electrolytes (Na+, K+, Ca2+-) / Hematocrit | x | x | |
| Metabolites (Glu / Lac) | x | ||
| Metabolites (Glu / Lac / Urea (BUN)) | x | ||
| Bilirubin | x | x | x |
| Optional modules | AutoQC module | AutoQC module | AutoQC module |
Technical documents
Access important product documentation including relevant certificates and other resources.
After clicking below, you will be redirected to eLabDoc, where you can select your local country-specific documents.
Related products
References
- F. Hoffmann-La Roche Ltd. cobas® b 221 system Operators Manual. (v20). 2025
- World Health Organization (2010), WHO guidelines on drawing blood: best practices in phlebotomy, pp31-32.
- Hambsch et al. (2015). Clin Transl Sci 8. 857-870.
- Ekström et al. (2019). Calculated arterial blood gas values from a venous sample and pulse oximetry: Clinical validation. PLoS ONE 14(4):e0215413.
- Kamperidis et al. (2018). Optimizing acute non-invasive ventilation care in the NHS; the v-TAC approach. Thorax 2018;73(Suppl 4):A1–A282.