cobas® b 221 system

cobas b 221 is more than a blood gas analyzer

IVD For in vitro diagnostic use.
cobas b 221 system

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Benchtop analyzer which gives high-quality¹ results in less than 2 minutes

Comprehensive testing menu covers 18 of the most important critical-care blood parameters including: blood gases, electrolytes, co-oximetry and metabolites.


Fast diagnosis

  • Results in less than 2 minutes to support timely clinical decision making.


Flexibility in setup

  • The cobas b 221 system meets your varying test needs with a flexible and comprehensive parameter menu.


Confidence in result quality

  • High-quality results where and when you need them.The cobas b 221 system is intended to be operated in laboratories of hospitals as well as in the point of care setting.


Minimal maintenance

  • The cobas b 221 system is designed for minimal maintenance. The electrodes are maintenance free allowing you to focus more on what matters.

cobas b 221 system versions²

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cobas b 221 system versions²



2 4 6
Blood gases (pH, pO2, pCO2, pH) / Co-oximetry x x x
Electrolytes (Na+, K+, Ca2+-) / Hematocrit   x x
Metabolites (Glu / Lac)     x
Metabolites (Glu / Lac / Urea (BUN))     x
Bilirubin x x x



  1. F.J. Ameijeiras, B.G. Ponce. 2010. Aspectos analíticos del analizador de gases Cobas® b 221 (Roche Diagnostics) Analytical aspects of Cobas® b 221 (Roche Diagnostics) blood gas analyzer. Revista del Laboratorio Clínico; Volume 3, Issue 3, July-September 2010, Pages 118-128
  2. Roche Diagnostics, 2022. cobas b 221 system operators manual version 19.0. pp. 35.


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  • Throughput

    up to 50 samples/hour

  • Time to result

    less than 2 minutes with whole-blood sampling

  • Module

    Optional module for automatic quality control

  • Parameter combinations

    Three different parameter combinations (see table below) including glucose, lactate, urea and bilirubin

  • Maintenance

    Durable, low-maintenance sensors

  • Touchscreen

    Easy-to-use touchscreen and intuitive user interface

  • Trending acid-base maps

    Trending acid-base maps to support clinical decisions

  • Reagent tracking

    Control reagents consumption

  • Customizable

    Customizable features include a user-definable display and two types of sample application

  • Connectable

    Connectable to your network via cobas® infinity POC for remote control and for comprehensive data management

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