cobas p 480 instrument

Automating your primary vial pre-processing steps

IVD For in vitro diagnostic use.
cobas p 480 instrument

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cobas p 480 Instrument Overview.


Removes caps from primary tubes for testing on the cobas® 4800, 6800 or 8800 Systems

Up to 1,536 samples in an 8-hour shift

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Recaps sample vials with new caps to avoid contamination

Up to 1,536 samples in an 8-hour shift



Aliquots configurable volumes from PreservCyt®, SurePath™ and cobas® PCR Cell Collection Media primary vials into barcode matched secondary tubes.

Up to 672 samples in an 8-hour shift

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reagent addition & heating
Reagent addition & heating


Addition of cobas® Sample Prep Buffer and incubation of specimens collected in SurePathmedium to reverse cross-linking and free nucleic acids for testing1,*

Up to 1,536 samples in an 8-hour shift

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Cross-linking process
Advanced contamination prevention

The cobas 480 Instrument uses a combination of physical, software, and process-based controls to ensure confidence in sample and result integrity.

Advanced liquid-handling technologies

Compressed O-Ring Expansion (CO-RE) Tip Technology


Reduces aerosol production during tip ejection

Total Aspirate and Dispense Monitoring (TADM)


Real-time monitoring of aspiration and dispensing steps

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Anti-droplet Control (ADC)


Continually monitors pipetting channel pressure and adjusts in real time

Software and process controls

Achieve process reliability and full data tracking with the intuitive software and process controls of the cobas p 480 Instrument. Featuring easy-to-use software and a simple and intuitive interface, you can keep your pre-analytic processes under complete control.

  • Sample chain-of-custody tracking via barcode matching
  • Barcode tracking for all samples, reagents and consumables
  • Advanced pipetting technology reduces opportunities for contamination to ensure sample integrity
  • Printable reports capture sample IDs, sample errors, and reagent lot and expiration information
Pre-analytic efficiency

The cobas p 480 Instrument improves laboratory efficiency by allowing valuable technician time to be used more productively, eliminating repetitive, manual sample handling, improving workflow and reducing risk of contamination, human error and workplace injury.

Package inserts

Access package inserts through your country’s Roche Diagnostics Website.

* Automation of the SurePath™ pre-treatment procedure with the cobas p 480 Instrument has not been reviewed by FDA and is not approved in the US.



  1. Kiernan JA. Preservation and retrieval of antigens for immunohistochemistry—methods and mechanisms. Part 2: Retrieving masked antigens. Accessed December 20, 2016. The Cutting Edge. 2005:5-11.


Ordering Information

Technical Documents

Access Material Data Sheets, Certificates of Analysis, and other product documentation.

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