LightCycler® PRO system

IVD For in vitro diagnostic use.
LightCycler<sup>®</sup> PRO system
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Light the way from research to clinical diagnostics

The LightCycler® PRO system combines the functionalities of instrumentation, consumables, reagents, and data management to support a semi-automated workflow for polymerase chain reaction-based nucleic acid testing.1

Leveraging the robustness and proven technology of the LightCycler® 480,* the LightCycler PRO integrates innovative technology and Roche manufacturing to deliver accurate real-time PCR results and an improved user experience for your lab.

Increase your lab’s testing capabilities

TIB Molbiol provides a comprehensive assay menu for both research and clinical diagnostic uses.** This includes the LightMix® Modular Assay Kits, which are meticulously tailored for optimal performance on the LightCycler® PRO system, ensuring user-friendly convenience without compromising result quality, reliability, or reproducibility.

Close-up image of a lab technician using the touch screen on the LightCycler® PRO System

Delivers multiplex precise data analysis

The new LightCycler® PRO software improves functionality, performance, and precise data analysis.2

  • A new adaptive color compensation function across the 7 channels to minimize color crosstalk. This methodology is optimized for use with LightMix® modular assays.

  • An updated fit points algorithm that automatically determines the Cq value from the PCR run data for confidence in results calling

TIB Molbiol LightMix Modular Gastro Bacteria 7-target multiplexed assay

TIB Molbiol LightMix® Modular Gastro Bacteria 7-target multiplexed assay. Optimized to detect 7 different targets from a single well.

LightCycler® PRO System, dilution series 11 copies to 110 copies, demonstrating high precision and accuracy.

LightCycler® PRO System, dilution series 10^1 to 10^8 copies. Demonstrating high precision and accuracy.

Benefits at a glance

Benefits at a glance

Have confidence in the accuracy of your results

  • Patented Vapor Chamber Mount design delivers precise temperature regulation and enhanced sensitivity
  • Optical module design for uniform excitation, edge effect prevention, simultaneous data capture, and flexible dye options and detection formats

Adapt quickly to your lab’s evolving testing needs

  • New seven-channel multiplexing increases hourly throughput and enables greater diversity of tests per run
  • Thermal Cycler with interchangeable 96- or 384-well plates offers variable throughput options to support your lab’s specific needs

Streamline workflow efficiency with easy data management options

  • Large, 40 cm touchscreen improves user interface and enables easy access to workflow and data management options
  • Easy import/export of data, LIS connectivity, and remote access

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Overview

Ordering Information

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Product specification 

Value

General characteristics 

Automation 

  • Automatic run/start when loading a valid plate and existing plate setup

  • HL7-based host interface to a customer LIS (Laboratory Information System)

  • Barcode-assisted scanning of multi-well plates

Remote monitoring 

Remote access to host computer for process monitoring and reviewing data

Data management 

Compatibility with 21 CFR Part 11

Interfaces 

  • 6 x USB 2.0 on the back of the device

  • 2 x USB 2.0 on the front of the device

  • 1 x HDMI for external display on the back of the device

  • 1 x Ethernet port on the back of the device

Temperature control 

Peltier-based heating/cooling from 20°C-99°C

Integrated vapor chamber for optimal temperature distribution

Heating rate 

96-well-block: 4.4 °C/s

384-well-block: 4.8 °C/s

Filter 

7 Excitation

7 Emission

Detector 

CMOS Camera

Light source 

White LED lamp

Dimensions and weight 

Instrument dimensions 

45.3 x 54.3 x 50.4 cm (W x H x D)

Instrument weight 

54.5 kg

Power supply 

Voltage 

100-240 VAC

Line frequency 

50/60 Hz

Technical Documents

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Explore the LightCycler® PRO system

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    Do you have questions about our products or services? We’re here to help. Contact a Roche representative in your region.

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    *For research use only. Not for use in diagnostic procedures.

    **Some assays are only available through TIB Molbiol or Roche. Assay availability varies by country. Contact your local representative for more information.

    References

    1. F. Hoffmann-La Roche Ltd. LightCycler® PRO System SW1.2 User Guide 2.0. (v2.0). 2025.
    2. F. Hoffmann-La Roche Ltd. V&V Report: DH-02714.04-500B. Data on file.