MagNA Pure 96 System

Fully automated, high throughput nucleic acid purification

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The MagNA Pure 96 System ensures purity, reproducibility, and laboratory efficiency for a successful molecular diagnostic workflow. Process up to 96 samples in less than one hour and increase your laboratory productivity to meet your changing needs.

MagNA Pure 96 System

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Effortless purification, confidence from automation

High-throughput instrument for automated nucleic acid purification
Proven performance delivering reproducible and consistent yields
Process up to 96 samples in less than one hour
Support for a broad range of samples for use in a variety of downstream applications
Simplified workflow with ready-to-use prefilled reagent trays and streamlined kit offerings
Full traceability and connection to your laboratory information system
Minimized handling errors via detection, guidance and surveillance processes
Contamination prevention with built-in UV lamp and drop catcher plus CO-RE Tip technology

Prefilled, barcoded, and ready-to-use reagent kits

MagNA Pure 96 Kits are prefilled and ready-to-use reagent trays that can be easily loaded, ensuring ease of use and safety. Kits and consumables are barcoded and read by the MagNA Pure onboard scanner for inventory check, loading errors, and process documentation.

An intuitive user interface

MagNA Pure 96 Software includes an intuitive graphical user interface, providing all instructions to operate the system, such as sample loading to run start. The software detects loading errors and provides information to the user for the appropriate corrective action.

A new dimension in productivity

Experience high throughput automation combined with high performance while increasing your laboratory productivity to meet your changing needs. Magnify your lab’s efficiency with seamless data management and expand your capacity for diverse day to day throughput needs.

Further information

For more detailed information about the MagNA Pure 96 System, visit magnapure96.com.

Registration status

IVD

Package inserts

Access package inserts through your country’s Roche Diagnostics website.

Assay menu

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Download protocols

The MagNA Pure 96 System protocols are available for download from the table below (note: not available for download in the US).

Applications are very flexible, due to a diversity of software purification protocols using barcoded, prefilled trays with ready-to-use reagents.
MagNA Pure 96 kits are designed profiting from our more than ten year expertise in magnetic glass particle technology. We have streamlined the purification process to a very small number of reagents, consumables and steps.

Optimized preprogrammed purification protocols ensure routine sample handling and high quality, reproducible nucleic acid yields. Choose the appropriate purification protocol for your sample material and target nucleic acid.

MagNA Pure 96 System protocols

Target	Protocol name	Input sample type and sample volumes													Elution volume	Run time*** (h:mm)
Target	Protocol name	Whole blood	Plasma (citrate)	Plasma (EDTA)	Serum	Swabs	BAL*	Sputum	CSF	Urine	Stool	Cultured cells	Fresh-frozen tissue	FFPET**	Elution volume	Run time*** (h:mm)
Baterial, fungal and viral NA	Pathogen Universal 200 ¹	200 μL													50, 100 μL	1:00
	Viral NA Plasma SV ¹			50, 100, 200 μL												1:00
	Viral NA Plasma ext lys SV ¹ Protocol optimized with external lysis reagent	350, 450 μL lysate from 100, 200 μL sample														1:00
	Viral NA Universal SV ¹	50, 100, 200 μL			50, 100, 200 μL											1:00
	Pathogen Universal 500 ²	500 μL														1:30
	Pathogen Universal 1000 ²	1000 μL														1:40
	Viral NA Plasma LV ²			500 μL												1:10
	Viral NA Plasma LV 1000 ²			1000 μL												1:20
	Viral NA Plasma ext lys LV ² Protocol optimized with external lysis reagent		1000 μL lysate from 500 μL sample													1:10
	Viral NA Universal LV ²		500 μL		500 μL											1:30
	Viral NA Universal LV 1000 ²		1000 μL		1000 μL											1:30
Genomic DNA	DNA Blood SV ¹ Recommended for elution of predominantly double-stranded DNA	50, 100 or 200 μL ≤ 2x10⁶ cells/samples													50, 100 μL	1:00
	DNA Blood ext lys SV ¹ Protocol optimized with external lysis reagent	300, 350, or 450 μL lysate from 50, 100, 200 μL sample													50, 100 μL	0:50
	DNA Cells SV ¹											Up to 5x10⁵ cultured cells in 200 μL PBS			100 μL	1:00
	DNA Tissues SV ¹												Up to 5 mg in 200 μL		100, 200 μL	1:20
	DNA FFPE SV ¹													200 μL lysate from 2x5 μL sections	50, 100 μL	1:00
	DNA Blood LV ²	500 μL (≤ 1x10⁷ cells/ml)													100, 200 μL	1:20
	DNA Blood LV 1000 ²	1000 μL (≤ 1x10⁷ cells/ml)													100, 200 μL	1:30
	DNA Blood ext lys LV ² Protocol optimized with external lysis reagent	1000 μL lysate from 500 μL sample (≤ 1x10⁷ cells/ml)													100, 200 μL	0:50
	DNA Cells LV ¹											Up to 1x10⁶ cultured cells in 200 μL PBS			100, 200 μL	1:20
	DNA Tissue LV ²												Up to 25 mg in 200 μL		200 μL	1:20
Cell-free NA	cfNA ss 2000 ² Protocol optimized for single-stranded DNA			2000 μL											50, 100 μL	2:00
	cfNA ss 4000 ² Protocol optimized for single-stranded DNA			4000 μL											50, 100 μL	2:20
	cfNA ds 2000 ² Protocol optimized for single-stranded DNA			2000 μL											100, 200 μL	2:20
	cfNA ds 4000 ² Protocol optimized for single-stranded DNA			4000 μL											100, 200 μL	2:50
Total RNA	Cellular RNA LV ³											Up to 1x10⁶ cultured cells in 200 μL PBS			50, 100, 200 μL	1:30
	RNA Blood LV 400 ³	900 μL stabilized whole blood from 400 μL whole blood													50, 100, 200 μL	1:30
	RNA Blood LV 800 ³	1800 μL stabilized whole blood from 800 μL whole blood													100, 200 μL	1:30
	RNA PAXgene LV ³	PAXgene pellet in 400 μL PBS													100, 200 μL	1:30
	RNA PAXgene Half Tube LV ³	Half PAXgene pellet in 200 μL PBS													50, 100 μL	1:30
	RNA Tissue FF Standard LV ³												Up to 10 mg in 350 μL		50, 100, 200 μL	1:30
	RNA Tissue FF High LV ³												Up to 25 mg in 700 μL		100, 200 μL	1:30
	RNA Tissue FFPE LV ³													150 μL lysate from 2x5 μm sections	50, 100 μL	1:30
Liquid handling	Sample Transfer to the processing cartridge	50 µL to 1000 µL														NA
	Archive Plate Transfer for archiving purposes	5 μL to 200 μL														NA
	PCR Setup with Mixing															NA
	PCR Setup without Mixing															NA
¹MagNA Pure 96 DNA and Viral NA Small Volume Kit (cat. no. 06 543 588 001) ² MagNA Pure 96 DNA and Viral NA Large Volume Kit (cat. No. 06 374 891 001) ³MagNA Pure 96 Cellular RNA Large Volume Kit (cat no. 05 467 535 001) ^{To get better results, Roche provides various External Lysis Buffers: MagNA Pure cfNA Buffer Set (Cat. no. 07 794 398 001), MagNA Pure 96 External Lysis Buffer (Cat. no. 06 374 913 001), MagNA Pure 96 Bacterial Lysis Buffer (Cat. no. 06 374 921 001), MagNA Pure 96 DNA Tissue Lysis Buffer (Cat. no. 06 640 702 001), MagNA Pure FFPET Buffer Set† (Cat. no. 08 447 144 001) and S.T.A.R. Buffer§ (Cat. no. 03 335 208 001). Please refer to the instructions for use manual for more details.}						^BAL - Bronchoalveolar Lavage ^FFPET - formalin-fixed paraffin-embedded tissue ^**These times are approximate and should only be used as a guidance. ^♰For general laboratory use. ^§For life science research only. Not for use in diagnostic procedures.