Micral-Test® strip

Quick, early and reliable detection of albumin in urine1,2,3

Micral-Test® strip

Reliable results to detect albumin in urine1,4

Normal urine contains very little protein: usually, less than 10 mg/dL or 100 mg per 24 hours is excreted.5 Persistent microalbuminuria indicateds a high probability of damage to the kidney glomerular filtration capacity.Albuminuria is the term used when albumin levels reach >200 mg/L in the urine.6 Microalbuminuria is the term used when albumin levels in the urine are 20-200 mg/L.6 Even though only a small amount of albumin is present in the urine in microalbuminuria, this can be an indicator that the patient has the beginnings of kidney damage.7 Patients with microalbuminuria have an elevated risk of developing progressive renal disease as well as increased risk of cardiovascular disease.8 Action taken by a healthcare practitioners (HCP) at this stage can halt or reverse the damage to the kidneys.12

The Micral-Test strip is an easy to use test designed to deliver quick and accurate results, specific for human albumin and sensitive across the diagnostic range. Suitable for all patient groups, the Micral-Test strip is a cost efficient way to gain actionable health information.9,11

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Specific for human albumin9

The Micral-Test® strip is based on an immuno­logical test principle using gold-labelled monoclonal antibodies with a chromogenic color indicator enabling confidence in results.

 

Sensitive across the diagnostic range9,10

 

The Micral-Test® is used as an aid in early diagnosis of microalbuminuria via detection of microalbumin in urine.1,2,3

 

Fast and easy

 

After 60 seconds, the result is ready for visual reading with a convenient color comparison on the strip box. The Micral-Test strip is easy to handle.2

 

Special design of the Micral-Test strip delivers accurate results4,9

 

  • The Immunological test principle with monoclonal antibodies is highly specific for human albumin
  • The urine sample is absorbed by the test strip and transferred through the following two zones before reaching the detection pad:
    Zone 1 – Conjugate Fleece contains free gold-labelled antibodies
    Zone 2 – Capture Matrix Fleece with fixed human serum albumin (HSA)
Micral-Test® strip illustration

Three simple testing steps

Step 1

Dip the test strip into the urine for 5 seconds 

Step 2

Place the strip on a nonabsorbent surface or across the top of the collection cup to allow excess urine to drain, wait for 1 minute

Step 3

Compare the color of the detection pad on the strip with the color scale on the test strip vial

The expected value for normal urine samples

  • The albumin concentration of an average urine specimen should not exceed 15 – 20 mg/L13
  • Clinical diabetic nephropathy is indicated when microalbuminuria (> 20 mg/L) is present in at least two of the three morning urine samples9
  • A normal microalbuminuria value does not necessarily rule out renal disease10

References

 

  1. Solarin, A. U. & Njokanma, F. O., 2015. The Micral-Test as a screening tool to detect microalbuminuria-albuminuria in children 5 - 15 years old with sickle cell anaemia, Lagos State University Teaching Hospital. SAJCH, 9(2), pp. 41-44.
  2. Afifa, K. & Asma, S. B., 2016. Screening for Nephropathy in Diabetes Mellitus: Is Micral-Test Valid among All Diabetics?. International Journal of Chronic Diseases, Volume 2016(Article ID 2910627), p. 7.
  3. Król, E. & Rutkowski, B., 2009. Early Detection of Chronic Kidney Disease: Results of the PolNef Study. Amercian Journal of Nephrology, Volume 29, p. 264–273.
  4. Amjad, A. & Muhammad, S., 2017. Role of Micral Test For the Detection of Microalbuminurea. Med. Forum, 28(8), pp. 36-38.
  5. Strasinger, S. K. & Di Lorenzo, M. S., 2007. Urinalysis and Body Fluids. 5th ed. Philadelphia(PA): F. A. Davies Company. p 57.
  6. Hasslacher. C. 1993. Clinical significance of microalbuminuria and evaluation of the micral-test. Clin Biochem. Volume 26 (4). pp. 283-287.
  7. Glassock, R. J., 2010. Is the presence of microalbuminuria a relevant marker of kidney disease?. Curr Hypertens Rep, 12(5), p. 365.
  8. Singh, A. & Satchell, S. C., 2011. Microalbuminuria: causes and implications. Pediatr Nephrol, 26(11), p. 1957.
  9. Micral-Test®, M. S., 2018. eLabDoc. [Online] Available at: https://dialog1.roche.com. [Accessed 24 April 2018].
  10. American Diabetes Association. “Consensus development conference on the diagnosis and management of nephropathy in patients with diabetes mellitus.” Diabetes Care. 1994;17:1357-1361.
  11. Srisubat A. & Sriratanaban J.. 2014. Cost-effectiveness of annual microalbuminuria screening in Thai diabetics. Asian Biomedicine 8(3). pp. 371-379
  12. Cembrowski G.. 1990. Testing for Microalbuminuria: Promises and Pitfalls. Laboratory Medicine. Volume 21. pp. 491-496.
  13. Chemstrip® Micral®. M.S. 2012.eLabDoc. [Online] Available at: https://dialog1.roche.com [Accessed 4 January 2018].

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