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"Name": "Storage Conditions (Product)",
"Value": "Store at 2-8° C. Do not freeze. The user must validate any storage conditions other than those specified in the package insert.",
"Language": "en",
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"Name": "Content",
"Value": "CONFIRM anti-c-KIT (9.7) contains sufficient reagent for 50 tests.
1 - 5 ml dispenser contains approximately 25 µg of a rabbit monoclonal antibody directed against the C-terminal domain of c-KIT protein. The antibody is diluted in Tris buffered saline containing carrier protein and preservative.
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"Value": "This antibody is intended for in vitro diagnostic (IVD) use.
Ventana Medical Systems' (Ventana) CONFIRM anti-c-KIT (9.7) Primary Antibody is a rabbit monoclonal antibody (IgG) directed against the C terminal (intracellular) domain of c- KIT protein and recognizes both wild type and mutant forms of the c-KIT protein. This antibody is intended for laboratory use, via light microscopy, for the qualitative detection of c-KIT protein in formalin-fixed, paraffin-embedded tissue on a Ventana automated slide stainer. CONFIRM anti-c-KIT (9.7) specifically binds to antigen located in the cell membrane and cytoplasmic regions of normal mast cells, interstitial cells of Cajal (ICC), and gastrointestinal stromal tumors (GISTs).This antibody does not cross react with PDGFR alpha, c-FMS or Flt-3. The presence of c-KIT protein in GISTs is helpful diagnostically in the identification of GISTs and their separation from other stromal lesions.1 The clinical interpretation of any staining, or the absence of staining, must be complemented by morphological studies and evaluation of proper controls. Evaluation must be made by a qualified pathologist within the context of the patient’s clinical history and other diagnostic tests. Prescription only.
1. Sarlomo-Rikala M, Kovatich H, Barusevicius A, Miettinen M. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol (1998) 11: 728-734.",
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"Name": "Background Information",
"Value": "The c-KIT gene was cloned and characterized by Yarden et al. in 1987.2 Its oncoprotein product is an approximately 145 kD to 125 kD transmembrane glycoprotein which is structurally similar to platelet derived growth factor receptor (PDGFR). The protein has associated tyrosine kinase activity similar to that of several growth factor receptors and to the transforming proteins of the src family. The coding sequence is consistent with an extracellular ligand binding domain and an intracellular kinase domain. This suggests that c-KIT may be involved in signal transduction when bound by its ligand, stem cell factor, and may stimulate mitogenic activity. 2,3 C-KIT is expressed in other normal as well as neoplastic tissues including mast cells and the interstitial cells of Cajal. These cells are the pacemaker cells of the gastrointestinal tract resulting in gastrointestinal motility3. Activating mutations in the tyrosine kinase or juxtamembrane domains of the c-KIT gene have been identified. These findings suggest that GISTs arise from or show differentiation towards the interstitial cells of Cajal. The presence of c-KIT protein in GISTs is helpful diagnostically in the identification of GISTs and their separation from other stromal lesions.1
1. Sarlomo-Rikala M, Kovatich H, Barusevicius A, Miettinen M. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol (1998) 11: 728-734.
2. Yarden Y, Kuang W, Yang-Feng T, Coussens L, Munemitsu S, Dull T, Chen E, Schlessenger J, Franke U, and Ullrich A. Human prot-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO Journal. 6:3341- 3351, 1987.
3. Heinrich M, Blanke C, Druker B, and Corless C. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol. 20: 1692-703., 2002.",
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"Value": "CONFIRM anti-c-KIT (9.7) may be used as the primary antibody for immunohistochemical staining of paraffin tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and cover slipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.4
CONFIRM anti-c-KIT (9.7) is optimally diluted for use with Ventana detection kits and automated slide stainers. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the Ventana automated slide stainer to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen containing slide a coverslip solution is applied in the slide stainer. Staining is completed after incubation with a substrate chromogen and optional counterstaining. For more detailed information on instrumeinstrument operation, refer to the appropriate Ventana automated slide stainer Operator's Manual.
4. Taylor C (Clive Roy). Immunomicroscopy : a diagnostic tool for the surgical pathologist / Clive Roy Taylor; James L. Bennington, consulting editor. Major problems in pathology; v. 19 Philadelphia: Saunders, 1986.",
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1. Sarlomo-Rikala M, Kovatich H, Barusevicius A, Miettinen M. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol (1998) 11: 728-734.",
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