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The detection of CD4 by immunohistochemistry (IHC) with the CONFIRM anti-CD4 (SP35) Rabbit Monoclonal Primary Antibody (CONFIRM anti-CD4 (SP35) antibody), when evaluated with other markers, may be used to aid in the identification of normal helper T-cells and sub-classification of T-cell lymphoma. The cellular staining pattern for CONFIRM anti-CD4 (SP35) antibody is membranous.
1. Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications, 5th edition. Vol 5. Amsterdam, Netherlands: Elsevier; 2019.
2. Naeim F. Principles of Immunophenotyping. In: Naeim F, Rao PN, Grody WW, eds. Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches. Cambridge, MA: Academic Press; 2009.
3. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Vol 4. Lyon, France: International Agency for Research on Cancer; 2008.
4. Higgins RA, Blankenship JE, Kinney MC. Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphoma. Arch Pathol Lab Med. 2008;132(3):441-461.",
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One 5 mL dispenser of CONFIRM anti-CD4 (SP35) antibody contains approximately 12.5 μg of a recombinant rabbit monoclonal antibody.
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There is no known non- specific antibody reactivity observed in this product.
CONFIRM anti-CD4 (SP35) antibody is a recombinant rabbit monoclonal antibody produced as purified cell culture supernatant.
Refer to the appropriate VENTANA detection kit method sheet for detailed descriptions of: Principle of the Procedure, Material and Methods, Specimen Collection and Preparation for Analysis, Quality Control Procedures, Troubleshooting, Interpretation of Staining, and Limitations.",
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