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1-4 Immunohistochemical staining of HHV-8 is a valuable tool to detect the presence of HHV-8, usually to aid in the diagnosis of Kaposi sarcoma.
1. Suthaus J, et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in thedevelopment of multicentric Castleman disease in mice. Blood. 2012; 119:5173-81.
2. Staskus K, et al. Cellular tropism and viral interleukin-6 expression distinguish humanherpesvirus 8 involvement in Kaposi’s sarcoma, primary effusion lymphoma, andmulticentric Castleman’s disease. Journal of Virology. 1999; 73:4181-7.
3. Nagata N, et al. Diagnostic value of endothelial markers and HHV-8 staining ingastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging. World JGastroentrol. 2013; 19:3608-14.
4. Sakakibara S, et al. Viral interleukin-6: Role in Kaposi’s sarcoma-associated herpesvirusassociatedmalignancies. J Interferon Cytokine Res. 2011; 31:791-801.",
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