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Do not freeze.", "Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "HHV-8 Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the HHV-8 protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Intended Use" }, { "Name": "Content", "Value": "One dispenser of this antibody contains sufficient prediluted reagent for 50 tests.", "Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Human herpesvirus 8 (HHV-8) also known as Kaposi sarcoma-associated herpes virus has been found to be the likely etiologic agent of Kaposi sarcoma.1-4 Immunohistochemical staining of HHV-8 is a valuable tool to detect the presence of HHV-8, usually to aid in the diagnosis of Kaposi sarcoma.

1. Suthaus J, et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in thedevelopment of multicentric Castleman disease in mice. Blood. 2012; 119:5173-81.
2. Staskus K, et al. Cellular tropism and viral interleukin-6 expression distinguish humanherpesvirus 8 involvement in Kaposi’s sarcoma, primary effusion lymphoma, andmulticentric Castleman’s disease. Journal of Virology. 1999; 73:4181-7.
3. Nagata N, et al. Diagnostic value of endothelial markers and HHV-8 staining ingastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging. World JGastroentrol. 2013; 19:3608-14.
4. Sakakibara S, et al. Viral interleukin-6: Role in Kaposi’s sarcoma-associated herpesvirusassociatedmalignancies. J Interferon Cytokine Res. 2011; 31:791-801.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "HHV-8 (13B10) Mouse Monoclonal Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections. In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and a coverslip applied. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.

This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. Refer to the Tables in the Instructions for Use section for recommended staining protocols. Each step in the staining protocol includes incubation for a precise time at a specific temperature. At the end of each incubation step, the sections are rinsed by the BenchMark IHC/ISH instruments to stop the reaction and remove unbound material that would hinder the desired reaction in subsequent steps. To minimize evaporation of the aqueous reagents from the specimen-containing slide, a coverslip solution is applied in the slide stainer. For more detailed information on instrument operation, refer to the appropriate BenchMark IHC/ISH instruments Operator’s Manual.", "Language": "en", "Country": "XG", "Code": "Principle" }, { "Name": "Product Purpose", "Value": "HHV-8 Mouse Monoclonal Primary Antibody is intended for laboratory use in the detection of the HHV-8 protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This antibody is intended for in vitro diagnostic (IVD) use.", "Language": "en", "Country": "XG", "Code": "Product Purpose" } ] } } ] }

HHV-8 (13B10) Mouse Monoclonal Antibody

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HHV-8 (13B10) Mouse Monoclonal Antibody

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